Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Djavad Mowafaghian Centre for Brain Health and Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
Neurobiol Aging. 2022 Jan;109:192-194. doi: 10.1016/j.neurobiolaging.2021.09.022. Epub 2021 Oct 3.
Sex differences are well-established in Alzheimer's disease (AD) frequency and pathogenesis, but are not mechanistically understood. Accelerated epigenetic age has been associated with both cognitive aging and AD pathophysiology, but has not been studied by sex in AD or related cognitive impairment. Using the ADNI cohort, we found that none of sex, cognitive impairment diagnosis, nor load of APOEε4 alleles (strongest genetic AD risk factor) were associated with epigenetic age acceleration (DNAmAge, Intrinsic DNAmAge, PhenoAge, or GrimAge), although females exhibit more accelerated epigenetic aging using the Skin & Blood clock in the transition from normal cognition to cognitive impairment than males.
性别差异在阿尔茨海默病（AD）的发病率和发病机制中得到了充分证实，但在机制上仍未得到解释。加速的表观遗传年龄与认知衰老和 AD 病理生理学都有关，但在 AD 或相关认知障碍中，尚未按性别进行研究。利用 ADNI 队列，我们发现，性别、认知障碍诊断或 APOEε4 等位基因（最强的 AD 遗传风险因素）的负担均与表观遗传年龄加速（DNAmAge、内在 DNAmAge、PhenoAge 或 GrimAge）无关，尽管女性在从正常认知向认知障碍过渡时，表观遗传衰老比男性更明显。
