Helen and Robert Appel Alzheimer's Disease Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY, USA.
Helen and Robert Appel Alzheimer's Disease Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Neuron. 2024 Apr 17;112(8):1208-1221. doi: 10.1016/j.neuron.2024.01.024. Epub 2024 Feb 22.
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are complex and multifactorial. The higher AD risk in women may serve as a clue to better understand these complicated processes. In this review, we examine aspects of AD that demonstrate sex-dependent effects and delve into the potential biological mechanisms responsible, compiling findings from advanced technologies such as single-cell RNA sequencing, metabolomics, and multi-omics analyses. We review evidence that sex hormones and sex chromosomes interact with various disease mechanisms during aging, encompassing inflammation, metabolism, and autophagy, leading to unique characteristics in disease progression between men and women.
阿尔茨海默病（AD）及其病因和进展的机制复杂且多因素。女性 AD 风险较高可能为更好地理解这些复杂过程提供线索。在本综述中，我们研究了表现出性别依赖性效应的 AD 相关方面，并深入探讨了潜在的生物学机制，整合了单细胞 RNA 测序、代谢组学和多组学分析等先进技术的研究结果。我们综述了证据表明，性激素和性染色体在衰老过程中与各种疾病机制相互作用，包括炎症、代谢和自噬，导致男女之间疾病进展的独特特征。
