School of Applied Mathematics and Physical Sciences, National Technical University of Athens, Athens, Greece.
Laboratory of Cognitive Neuroscience and Sensorimotor Control, University Mental Health, Neurosciences and Precision Medicine Research Institute "COSTAS STEFANIS", Athens, Greece; First Psychiatry Department, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece.
Psychiatry Res. 2021 Dec;306:114270. doi: 10.1016/j.psychres.2021.114270. Epub 2021 Nov 2.
Functional brain dysconnectivity measured with resting state functional magnetic resonance imaging (rsfMRI) has been linked to cognitive impairment in schizophrenia. This study investigated the effects on functional brain connectivity of Integrated Psychological Therapy (IPT), a cognitive behavioral oriented group intervention program, in 31 patients with schizophrenia. Patients received IPT or an equal intensity non-specific psychological treatment in a non-randomized design. Evidence of improvement in executive and social functions, psychopathology and overall level of functioning was observed after treatment completion at six months only in the IPT treatment group and was partially sustained at one-year follow up. Independent Component Analysis and Isometric Mapping (ISOMAP), a non-linear manifold learning algorithm, were used to construct functional connectivity networks from the rsfMRI data. Functional brain dysconnectivity was observed in patients compared to a group of 17 healthy controls, both globally and specifically including the default mode (DMN) and frontoparietal network (FPN). DMN and FPN connectivity were reversed towards healthy control patterns only in the IPT treatment group and these effects were sustained at follow up for DMN but not FPN. These data suggest the use of rsfMRI as a biomarker for accessing and monitoring the therapeutic effects of cognitive remediation therapy in schizophrenia.
使用静息态功能磁共振成像(rsfMRI)测量的功能性大脑连接障碍与精神分裂症的认知障碍有关。本研究调查了综合心理治疗(IPT)对 31 名精神分裂症患者功能性大脑连接的影响，IPT 是一种认知行为导向的团体干预方案。患者以非随机的设计接受 IPT 或同等强度的非特异性心理治疗。仅在治疗结束后 6 个月，IPT 治疗组观察到执行和社会功能、精神病理学和整体功能水平的改善证据，而在 1 年随访时部分得到维持。独立成分分析和等距映射(ISOMAP)是一种非线性流形学习算法，用于从 rsfMRI 数据构建功能连接网络。与 17 名健康对照组相比，患者表现出功能性大脑连接障碍，无论是整体还是特定的默认模式网络(DMN)和额顶网络(FPN)都有这种障碍。只有在 IPT 治疗组中，DMN 和 FPN 的连接才会朝着健康对照组的模式逆转，这些效果在 DMN 的随访中持续存在，但 FPN 则没有。这些数据表明，rsfMRI 可用作评估和监测精神分裂症认知矫正治疗疗效的生物标志物。
