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早产儿坏死性小肠结肠炎:单中心研究中的新生儿医疗和营养管理。

Necrotizing enterocolitis in the preterm: newborns medical and nutritional Management in a Single-Center Study.

机构信息

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University Hospital "P. Giaccone", Palermo, Italy.

University of Milan, Milan, Italy.

出版信息

Ital J Pediatr. 2021 Nov 14;47(1):226. doi: 10.1186/s13052-021-01180-8.

Abstract

Necrotizing enterocolitis (NEC) is a typical disorder of preterm newborns, with a high mortality and morbidity rate. The therapeutic and nutritional management of disease depends on several factors. Its prognosis is linked, in addition to the severity of the disease and the need for surgery, to a correct enteral feeding in these patients. This study aims to identify the clinical characteristics of 18 patients with NEC, evaluating the different therapeutic paths undertaken, the type of formula used and the survival rate of this population. Average time of enteral nutrition before the NEC onset was 11,3 ± 11,6 days, with an average fasting period since the onset of 24 ± 18.9 days. 77.8% of patients received surgery and resumed enteral nutrition 17.7 ± 17.9 days after the intervention. The overall survival rate of our cohort was 55.5%. More prospective studies are needed to evaluate the long-term outcomes of survived children with NEC.

摘要

新生儿坏死性小肠结肠炎(NEC)是早产儿的一种典型疾病,具有较高的死亡率和发病率。疾病的治疗和营养管理取决于多种因素。除了疾病的严重程度和手术的需要外,患儿的肠内喂养也与预后有关。本研究旨在分析 18 例 NEC 患儿的临床特征,评估不同的治疗途径、使用的配方类型以及该人群的存活率。NEC 发病前肠内营养的平均时间为 11.3±11.6 天,发病后禁食时间的平均时间为 24±18.9 天。77.8%的患儿接受了手术,术后恢复肠内营养的时间为 17.7±17.9 天。本队列的总体存活率为 55.5%。需要更多的前瞻性研究来评估 NEC 幸存患儿的长期预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af61/8591939/d3e9b3762880/13052_2021_1180_Fig1_HTML.jpg

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