Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Department of Rheumatology, Medical Corporation JR Hiroshima Hospital, Japan.
Intern Med. 2022 Jun 1;61(11):1785-1788. doi: 10.2169/internalmedicine.8104-21. Epub 2021 Nov 13.
We herein report the case of a 78-year-old woman who was diagnosed as having disseminated herpes zoster (DHZ) complicated with probable varicella-zoster pneumonia during maintenance therapy for microscopic polyangiitis. Because the patient had severe renal dysfunction, amenamevir administration was started to avoid any neurotoxicity of acyclovir, which is suggested to be optimal for treatment. It ameliorated her symptoms without any adverse events. This is the first report suggesting the efficacy of amenamevir in the treatment of severe herpes zoster infection with coexisting DHZ and probable varicella-zoster pneumonia. Amenamevir could thus be a treatment option for severe varicella zoster virus infections.
我们在此报告一例 78 岁女性病例，该患者在显微镜下多血管炎维持治疗期间被诊断为播散性带状疱疹（DHZ）合并可能的水痘-带状疱疹肺炎。由于患者肾功能严重受损，开始给予阿昔洛韦避免神经毒性，阿昔洛韦被认为是治疗的最佳选择。治疗后患者症状改善，无任何不良反应。这是首例报告提示阿昔洛韦治疗伴有 DHZ 和可能的水痘-带状疱疹肺炎的严重带状疱疹感染的疗效。因此，阿昔洛韦可能是治疗严重水痘带状疱疹病毒感染的一种选择。
