Babál P, Soler P, Brozman M, Jakubovsky J, Beyly M, Basset F
Komenský University, Department of Pathology, Bratislava, Czechoslovakia.
Oral Surg Oral Med Oral Pathol. 1987 Sep;64(3):348-52. doi: 10.1016/0030-4220(87)90016-8.
Monoclonal antibodies were used in histopathologic and immunohistologic studies of periapical granulomas. In cellular zones, plasma cells and lymphocytes predominated, with variable numbers of fibroblasts, macrophages, and polymorphonuclear leukocytes. Labeling with monoclonal antibodies disclosed relatively infrequent, usually scattered macrophages. Plasma cells were numerous and frequently clumped. The vast majority of lymphocytes were T cells, scattered individually or in small groups of three or four cells and dispersed throughout the granulomas without any topographic predilection, with prevalence of T-suppressor/cytotoxic cells over T-helper/inducer cells. Our findings of numerous plasma cells, which were in agreement with descriptions of numerous immunoglobulin-producing cells by other authors, imply the participation of antibody-mediated immune reactions in periapical granulomas. The presence of cell-mediated immunity, in spite of numerous T cells, could not be confirmed.
单克隆抗体被用于根尖肉芽肿的组织病理学和免疫组织学研究。在细胞区域，浆细胞和淋巴细胞占主导地位，还有数量不等的成纤维细胞、巨噬细胞和多形核白细胞。用单克隆抗体标记显示巨噬细胞相对少见，通常呈散在分布。浆细胞数量众多且常聚集成团。绝大多数淋巴细胞是T细胞，单个散在或三四个细胞聚成小群，分散于整个肉芽肿中，无任何部位偏好，且T抑制/细胞毒性细胞多于T辅助/诱导细胞。我们发现大量浆细胞，这与其他作者对众多产生免疫球蛋白细胞的描述一致，提示抗体介导的免疫反应参与了根尖肉芽肿的形成。尽管有大量T细胞，但细胞介导免疫的存在尚无法证实。
