Liu Jing-Hua, Deng Guangda, Ma Jing, Li Liang, Fang Yuxin, Li Songfeng, Lu Hai
Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Front Med (Lausanne). 2021 Oct 27;8:709522. doi: 10.3389/fmed.2021.709522. eCollection 2021.
To assess the demographic and treatment features of pediatric patients of Coats' disease with retinal cyst using wide-angle FA. A retrospective, hospital based, cross-sectional study. Pediatric patients of Coats' disease underwent wide-angle FA. A retrospective review of pediatric patients of Coats' disease who underwent wide-angle FA at a single center from January 2015 to July 2020. Demographic and treatment features were compared between patients with or without retinal cyst. Demographic and treatment outcomes. There were 123 pediatric Coats' patients in our study, and 18.70% (23/123) of the patients developed complications with retinal cyst, 73.9% (17/23) of the retinal cysts were located in the inferior-temporal quadrant and 82.6% (19/23) of the retinal cysts were located in the peripheral retina anterior to the vortex veins. Compared with patients without retinal cyst, patients with retinal cyst had more clock-hours of telangiectasia on FA (7.32 vs. 5.41, = 0.031), and may need more total treatments (7.47 vs. 3.53, = 0.023) including laser photocoagulation (4.08 vs. 2.31, = 0.019) or intravitreal anti-VEGF (3.13 vs. 2.23, = 0.039), and also required a longer time for telangiectasia resolution (22.33 vs. 18.53 months, = 0.043). Pediatric patients with Coats' disease complicated by retinal cyst presented with more clock-hours of telangiectasia on FA and needed more total treatments and longer time for telangiectasia resolution.
利用广角荧光素血管造影（FA）评估患有视网膜囊肿的Coats病小儿患者的人口统计学和治疗特征。一项基于医院的回顾性横断面研究。对患有Coats病的小儿患者进行广角FA检查。回顾性分析2015年1月至2020年7月在单一中心接受广角FA检查的Coats病小儿患者。比较有无视网膜囊肿患者的人口统计学和治疗特征。人口统计学和治疗结果。本研究中有123例Coats病小儿患者，18.70%（23/123）的患者出现视网膜囊肿并发症，73.9%（17/23）的视网膜囊肿位于颞下象限，82.6%（19/23）的视网膜囊肿位于涡静脉前方的周边视网膜。与无视网膜囊肿的患者相比，有视网膜囊肿的患者在FA上的毛细血管扩张钟点数更多（7.32对5.41，P = 0.031），可能需要更多的总治疗次数（7.47对3.53，P = 0.023），包括激光光凝（4.08对2.31，P = 0. .019）或玻璃体内抗VEGF治疗（3.13对2.23，P = 0.039），并且毛细血管扩张消退所需时间更长（22.33对18.53个月，P = 0.043）。患有视网膜囊肿并发症的Coats病小儿患者在FA上的毛细血管扩张钟点数更多，需要更多的总治疗次数以及更长的毛细血管扩张消退时间。
