广角荧光素血管造影对Coats病对侧眼血管异常的纵向检查：一项多中心研究
Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study.
作者信息
Jeng-Miller Karen W, Soomro Taha, Scott Nathan L, Rao Prethy, Marlow Elizabeth, Chang Emmanuel Y, Ells Anna, Chau Felix, Nudleman Eric, Calvo Charles M, Patel Nish, Schwartz Roy, Cernichiaro-Espinosa Linda A, Montoya Alexandrea Gabrielle, Goldstein Jessica, Harper C Armitage, Baumal Caroline R, Hartnett Mary Elizabeth, Harbour J William, Besirli Cagri G, Gupta Mrinali P, Chan R V Paul, Drenser Kimberly A, Capone Antonio, Murray Timothy G, Mukai Shizuo, Trese Michael T, Berrocal Audina M, Wong Sui Chien, Yonekawa Yoshihiro
出版信息
Ophthalmic Surg Lasers Imaging Retina. 2019 Apr 1;50(4):221-227. doi: 10.3928/23258160-20190401-04.
BACKGROUND AND OBJECTIVE
Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time.
PATIENTS AND METHODS
This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats' disease.
RESULTS
Three hundred fifty eyes of 175 patients with Coats' disease were analyzed. A total of 33 patients (18.8%) demonstrated abnormal fellow-eye findings: 14 (42.4%) telangiectasias, 18 (54.5%) aneurysms, six (18.2%) segmental non-perfusion, six (18.2%) leakage, and two (6.0%) vascular tortuosity. All eyes were asymptomatic, and none of the lesions progressed over time. There was no association between fellow-eye findings with severity of Coats' disease (P = .16), patient age (P = .16), or presence of systemic vascular disease (P = .16).
CONCLUSIONS
The vascular abnormalities in fellow eyes of patients with Coats' disease did not progress over time. Observation is a reasonable initial management strategy. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:221-227.].
背景与目的
已有文献报道了科茨病患者对侧眼中的视网膜血管异常，但这些异常的临床意义尚不清楚，其病变是否会随时间进展也不明确。
患者与方法
这是一项针对科茨病患者进行的国际多中心回顾性观察队列研究，旨在通过广角荧光素血管造影术观察对侧眼的异常情况。
结果
分析了175例科茨病患者的350只眼睛。共有33例患者（18.8%）对侧眼出现异常表现：14例（42.4%）有毛细血管扩张，18例（54.5%）有动脉瘤，6例（18.2%）有节段性无灌注，6例（18.2%）有渗漏，2例（6.0%）有血管迂曲。所有眼睛均无症状，且病变均未随时间进展。对侧眼的表现与科茨病的严重程度（P = 0.16）、患者年龄（P = 0.16）或全身血管疾病的存在情况（P = 0.16）之间均无关联。
结论
科茨病患者对侧眼的血管异常未随时间进展。观察是一种合理的初始治疗策略。[《眼科手术、激光与影像学杂志》2019年；50:221 - 227。]
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