Clinical Nursing Teaching and Research Section, Department of Anesthesiology, and Anesthesia Medical Research Center, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
National Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, and Key Laboratory of Diabetes Immunology, Ministry of Education, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
J Diabetes Res. 2021 Nov 3;2021:6581213. doi: 10.1155/2021/6581213. eCollection 2021.
Although type 1 diabetes is thought to be an organ-specific autoimmune disease, mediated by effective CD4 and CD8 T cells, it has recently become clear that B cells participate in the initiation and progress of this disease. Indeed, B cell deletion can prevent or reverse autoimmune diabetes in nonobese diabetic mice and even result in partially remaining cell function in patients with new-onset type 1 diabetes. This review summarizes the dual role of B cells in this process not only of pathogenic effect but also of immunoregulatory function in type 1 diabetes. We focus on the impact that B cells have on regulating the activation, proliferation, and cytokine production of self-reactive T cells along with regulatory T cells, with the aim of providing a better understanding of the interactions between T and B cells in immunopathogenesis and improving the efficacy of interventions for clinical practice.
虽然 1 型糖尿病被认为是一种器官特异性自身免疫性疾病，由有效的 CD4 和 CD8 T 细胞介导，但最近已经清楚，B 细胞参与了这种疾病的发生和进展。事实上，B 细胞缺失可以预防或逆转非肥胖型糖尿病小鼠的自身免疫性糖尿病，甚至导致新诊断的 1 型糖尿病患者的细胞功能部分保留。这篇综述总结了 B 细胞在这一过程中的双重作用，不仅具有致病性作用，而且在 1 型糖尿病中还具有免疫调节功能。我们重点讨论了 B 细胞对调节自身反应性 T 细胞和调节性 T 细胞的激活、增殖和细胞因子产生的影响，旨在更好地理解 T 细胞和 B 细胞在免疫发病机制中的相互作用，并提高临床干预措施的疗效。
