University of Maryland, Baltimore, MD, USA.
Veterans Affairs Medical Center, Brooklyn, NY, USA.
Int J Low Extrem Wounds. 2024 Jun;23(2):191-204. doi: 10.1177/15347346211054598. Epub 2021 Nov 15.
Wound healing is an important topic in modern medicine across many disciplines. Healing of all cutaneous wounds, whether accidentally sustained or intentionally created, requires the common yet complex set of interactions between the immune, circulatory, nervous, endocrine, and integumentary systems. Deficits in any of these systems or the molecular factors that mediate their communications can contribute to impaired healing of cutaneous wounds. While the stages of wound repair, angiogenesis, growth factors, and cytokines involved have been extensively studied, the role of the cutaneous nervous system in wound healing has not been well outlined. We have provided a basic overview of cutaneous innervation and wound repair for the dermatologic surgeon by outlining the normal cutaneous nervous anatomy and function and discussing the most important neuropeptides that mediate the wound healing process.
伤口愈合是现代医学中许多学科的一个重要课题。所有皮肤伤口的愈合，无论是意外还是故意造成的，都需要免疫、循环、神经、内分泌和皮肤系统之间常见而复杂的相互作用。这些系统中的任何一个系统或介导它们之间通讯的分子因素的缺陷都可能导致皮肤伤口愈合受损。虽然已经广泛研究了伤口修复、血管生成、生长因子和细胞因子的阶段，但皮肤神经系统在伤口愈合中的作用尚未得到很好的描述。我们通过概述正常的皮肤神经解剖和功能以及讨论介导伤口愈合过程的最重要的神经肽，为皮肤科医生提供了皮肤神经与伤口修复的基本概述。
