Aghamajidi Azin, Gorgani Melika, Shahba Faezeh, Shafaghat Zahra, Mojtabavi Nazanin
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Int Rev Immunol. 2023;42(3):199-216. doi: 10.1080/08830185.2021.1988591. Epub 2021 Nov 14.
Cardiovascular disease is the most common cause of death, which has the highest mortality rate worldwide. Although a diverse range of inflammatory diseases can affect the cardiovascular system, however, heart failure and stroke occur due to atherosclerosis. Atherosclerosis is a chronic autoinflammatory disease of small to large vessels in which different immune mediators are involved in lipid plaque formation and inflammatory vascular remodeling process. A better understanding of the pathophysiology of atherosclerosis may lead to uncovering immunomodulatory therapies. Despite present diagnostic and therapeutic methods, the lack of immunotherapy in the prevention and treatment of atherosclerosis is perceptible. In this review, we will discuss the promising immunological-based therapeutics and novel preventive approaches for atherosclerosis. This study could provide new insights into a better perception of targeted therapeutic pathways and biological therapies. [Formula: see text].
心血管疾病是最常见的死亡原因，在全球范围内死亡率最高。尽管多种炎症性疾病可影响心血管系统，但心力衰竭和中风是由动脉粥样硬化引起的。动脉粥样硬化是一种从小血管到大动脉的慢性自身炎症性疾病，不同的免疫介质参与脂质斑块形成和炎症性血管重塑过程。更好地理解动脉粥样硬化的病理生理学可能会带来免疫调节疗法。尽管有目前的诊断和治疗方法，但在动脉粥样硬化的预防和治疗中缺乏免疫疗法是显而易见的。在本综述中，我们将讨论基于免疫的有前景的治疗方法以及动脉粥样硬化的新型预防方法。本研究可为更好地理解靶向治疗途径和生物疗法提供新的见解。[公式：见正文]
