Yan Yue, Xie Chuanbo, Di Shi, Wang Zhonghao, Wu Minqing, Li Yanhong, Liu Yuying, Jiang Rou
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.
J Dev Orig Health Dis. 2022 Oct;13(5):550-555. doi: 10.1017/S2040174421000635. Epub 2021 Nov 15.
The aim of this study was to evaluate the association between prenatal and neonatal period exposures and the risk of childhood and adolescent nasopharyngeal carcinoma (NPC). From January 2009 to January 2016, a total of 46 patients with childhood and adolescent NPC (i.e., less than 18 years of age) who were treated at Sun Yat-sen University Cancer Center were screened as cases, and a total of 45 cancer-free patients who were treated at Sun Yat-sen University Zhongshan Ophthalmic Center were selected as controls. The association between maternal exposures during pregnancy and obstetric variables and the risk of childhood and adolescent NPC was evaluated using logistic regression analysis. Univariate analysis revealed that compared to children and adolescents without a family history of cancer, those with a family history of cancer had a significantly higher risk of childhood and adolescent NPC [odds ratios (OR) = 3.15, 95% confidence interval (CI) = 1.02-9.75, = 0.046], and the maternal use of folic acid and/or multivitamins during pregnancy was associated with a reduced risk of childhood and adolescent NPC in the offspring (OR = 0.07, 95% CI = 0.02-0.25, < 0.001). After multivariate analysis, only the maternal use of folic acid and/or multivitamins during pregnancy remained statistically significant. These findings suggest that maternal consumption of folic acid and/or multivitamins during pregnancy is associated with a decreased risk of childhood and adolescent NPC in the offspring.
本研究的目的是评估产前和新生儿期暴露与儿童及青少年鼻咽癌（NPC）风险之间的关联。2009年1月至2016年1月，中山大学肿瘤防治中心收治的46例儿童及青少年鼻咽癌患者（即年龄小于18岁）被筛选为病例组，中山大学中山眼科中心收治的45例无癌患者被选为对照组。采用逻辑回归分析评估孕期母亲暴露和产科变量与儿童及青少年鼻咽癌风险之间的关联。单因素分析显示，与无癌症家族史的儿童及青少年相比，有癌症家族史的儿童及青少年患儿童及青少年鼻咽癌的风险显著更高[比值比（OR）=3.15，95%置信区间（CI）=1.02 - 9.75，P = 0.046]，孕期母亲使用叶酸和/或多种维生素与后代患儿童及青少年鼻咽癌的风险降低相关（OR = 0.07，95%CI = 0.02 - 0.25，P < 0.001）。多因素分析后，仅孕期母亲使用叶酸和/或多种维生素仍具有统计学意义。这些发现表明，孕期母亲摄入叶酸和/或多种维生素与后代患儿童及青少年鼻咽癌的风险降低相关。
