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利用 SeN 开发新型荧光探针,用于可视化免疫治疗剂给药过程中内源性次溴酸 (HOBr) 的变化。

Harnessing SeN to develop novel fluorescent probes for visualizing the variation of endogenous hypobromous acid (HOBr) during the administration of an immunotherapeutic agent.

机构信息

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China.

出版信息

Chem Commun (Camb). 2021 Nov 25;57(94):12679-12682. doi: 10.1039/d1cc04832e.

DOI:10.1039/d1cc04832e
PMID:34779461
Abstract

By means of the formation of SeN, the ABT-Se and NDI-Se were developed to detect and visualize endogenous hypobromous acid (HOBr) in live cells. Specifically, the upregulation of HOBr was monitored by NDI-Se during the administration of an immunotherapeutic agent.

摘要

通过形成 SeN,ABT-Se 和 NDI-Se 被开发用于检测和可视化活细胞内的内源性次溴酸 (HOBr)。具体而言,在给予免疫治疗剂时,通过 NDI-Se 监测 HOBr 的上调。

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