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硒缺乏在关节病发病机制中的研究进展及其硒补充治疗。

Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment.

机构信息

School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, People's Republic of China.

Department of Odontology, Umeå University, 90187, Umeå, Sweden.

出版信息

Biol Trace Elem Res. 2022 Oct;200(10):4238-4249. doi: 10.1007/s12011-021-03022-4. Epub 2021 Nov 15.

DOI:10.1007/s12011-021-03022-4
PMID:34779998
Abstract

Selenium, an essential trace element for human health, exerts an indispensable effect in maintaining physiological homeostasis and functions in the body. Selenium deficiency is associated with arthropathies, such as Kashin-Beck disease, rheumatoid arthritis, osteoarthritis, and osteoporosis. Selenium deficiency mainly affects the normal physiological state of bone and cartilage through oxidative stress reaction and immune reaction. This review aims to explore the role of selenium deficiency and its mechanisms existed in the pathogenesis of arthropathies. Meanwhile, this review also summarized various experiments to highlight the crucial functions of selenium in maintaining the homeostasis of bone and cartilage.

摘要

硒是人体健康所必需的微量元素，在维持生理内环境平衡和发挥体内功能方面具有不可或缺的作用。硒缺乏与关节炎有关，如大骨节病、类风湿关节炎、骨关节炎和骨质疏松症。硒缺乏主要通过氧化应激反应和免疫反应影响骨和软骨的正常生理状态。本文旨在探讨硒缺乏在关节炎发病机制中的作用及其机制。同时，本文还总结了各种实验，强调了硒在维持骨和软骨内环境平衡方面的重要作用。

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本文引用的文献

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LncRNA MIAT regulated by selenium and T-2 toxin increases NF-κB-p65 activation, promoting the progress of Kashin-Beck Disease.硒和 T-2 毒素调控的长链非编码 RNA MIAT 增加 NF-κB-p65 的激活，促进了大骨节病的进展。
Hum Exp Toxicol. 2021 May;40(5):869-881. doi: 10.1177/0960327120975122. Epub 2020 Nov 25.
2
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies.硒代谢和硒蛋白在软骨稳态和关节病中的作用。
Exp Mol Med. 2020 Aug;52(8):1198-1208. doi: 10.1038/s12276-020-0408-y. Epub 2020 Aug 13.
3
Decreased Expression of Heat Shock Protein 47 Is Associated with T-2 Toxin and Low Selenium-Induced Matrix Degradation in Cartilages of Kashin-Beck Disease.
元素的影响：锌、铜和硒在骨关节炎中的新作用
Nutrients. 2025 Jun 21;17(13):2069. doi: 10.3390/nu17132069.
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Circulating Essential Trace Element and Mineral Levels in Female Patients with Knee or Concomitant Knee and Hip Osteoarthritis.膝关节或合并膝关节和髋关节骨关节炎女性患者的循环必需微量元素和矿物质水平
Biol Trace Elem Res. 2025 Jun 9. doi: 10.1007/s12011-025-04696-w.
5
The relationship between the composite dietary antioxidant index and rheumatoid arthritis risk in American adults: the mediating role of BMI.美国成年人复合膳食抗氧化指数与类风湿关节炎风险之间的关系：BMI的中介作用。
Front Immunol. 2025 Apr 9;16:1560570. doi: 10.3389/fimmu.2025.1560570. eCollection 2025.
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The association between composite dietary antioxidant index and rheumatoid arthritis: evidence from NHANES 2001-2020.复合膳食抗氧化指数与类风湿性关节炎之间的关联：来自2001 - 2020年美国国家健康与营养检查调查（NHANES）的证据
BMC Rheumatol. 2024 Dec 24;8(1):74. doi: 10.1186/s41927-024-00447-x.
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