Ma Guangbin, Zhang Shulin, Luo Yiyan, Zhang Chengcheng, Xu Weina, Wang Liyan
Weifang Hospital of Traditional Chinese Medicine, Weifang, P. R. China.
Penglai People's Hospital, Yantai, P. R. China.
BMC Rheumatol. 2024 Dec 24;8(1):74. doi: 10.1186/s41927-024-00447-x.
This study aimed to investigate the relationship between the composite dietary antioxidant index (CDAI) and rheumatoid arthritis (RA) using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2001 to 2020.
CDAI is based on the intake of vitamins A, C, E, manganese, selenium, and zinc from the diet. RA patients were identified through questionnaire responses. Weighted multivariate regression analysis was employed to examine the association between CDAI and RA. Additionally, restricted cubic splines were utilized to assess potential non-linear relationships. Subgroup analyses were used to explore whether the relationship between CDAI and RA remained consistent across subgroups (e.g., sex, age, smoking status, etc.). We also used interaction terms to assess whether these subgroup variables influence the relationship between CDAI and RA risk. Finally, we also performed sensitivity analyses to assess the robustness of the main findings after excluding patients with a history of diabetes.
The study included a total of 11,266 patients. After adjusting for all covariates, the multivariate logistic regression analysis showed that each unit increase in CDAI was associated with a 4% reduction in the odds of RA (odds ratio = 0.96, 95% confidence interval = 0.94-0.99). The incidence of RA was found to decrease as CDAI levels increased (P for trend < 0.05). In the restricted cubic spline analysis, a linear relationship between CDAI and RA was observed. Subgroup analyses and interactions demonstrated that the negative association between CDAI and RA was consistent across all subgroups and was influenced by smoking.
This study indicates a negative correlation between CDAI and RA, suggesting that CDAI may serve as a valuable and convenient marker for reducing the risk of RA in US adults.
Not applicable.
本研究旨在利用2001年至2020年美国国家健康与营养检查调查（NHANES）的数据，探讨复合膳食抗氧化指数（CDAI）与类风湿关节炎（RA）之间的关系。
CDAI基于饮食中维生素A、C、E、锰、硒和锌的摄入量。通过问卷回答确定RA患者。采用加权多变量回归分析来检验CDAI与RA之间的关联。此外，使用受限立方样条来评估潜在的非线性关系。亚组分析用于探讨CDAI与RA之间的关系在各亚组（如性别、年龄、吸烟状况等）中是否保持一致。我们还使用交互项来评估这些亚组变量是否影响CDAI与RA风险之间的关系。最后，我们还进行了敏感性分析，以评估排除有糖尿病病史的患者后主要发现的稳健性。
该研究共纳入11266名患者。在对所有协变量进行调整后，多变量逻辑回归分析显示，CDAI每增加一个单位，RA的发病几率降低4%（比值比=0.96，95%置信区间=0.94-0.99）。发现RA的发病率随着CDAI水平的升高而降低（趋势P<0.05）。在受限立方样条分析中，观察到CDAI与RA之间存在线性关系。亚组分析和交互作用表明，CDAI与RA之间的负相关在所有亚组中都是一致的，并且受吸烟影响。
本研究表明CDAI与RA之间存在负相关，提示CDAI可能是降低美国成年人RA风险的一个有价值且方便的指标。
不适用。
