Meghji S, Scutt A, Harvey W, Canniff J P
Department of Oral and Maxillo-Facial Surgery, Eastman Dental Hospital, London, England, U.K.
Arch Oral Biol. 1987;32(3):213-5. doi: 10.1016/0003-9969(87)90138-5.
Fibroblasts cultured in vitro from normal buccal tissue and from tissue from oral submucous fibrosis (OSF) associated with betel-nut chewing showed no significant difference in their rates of proliferation in culture, nor in the rate at which they hydrolysed the betel nut alkaloid arecoline to arecaidine. Basal rates of collagen synthesis were slightly higher in the OSF cells but, on addition of arecoline, the rate of collagen synthesis in normal and OSF cells was stimulated to the same level.
从正常颊部组织以及与嚼槟榔相关的口腔黏膜下纤维化（OSF）组织中体外培养的成纤维细胞，在培养中的增殖速率，以及它们将槟榔生物碱槟榔碱水解为槟榔次碱的速率方面，均未显示出显著差异。OSF细胞中胶原蛋白合成的基础速率略高，但加入槟榔碱后，正常细胞和OSF细胞中胶原蛋白的合成速率均被刺激到相同水平。
