具有稳定费城染色体（Ph1）嵌合现象的慢性髓性白血病中髓系和红系集落的细胞遗传学研究
Cytogenetic study of myeloid and erythroid colonies in chronic myeloid leukaemia with stable Ph1 mosaicism.
作者信息
Cramer P, Vainchenker W, Brouet J C, Berger R
机构信息
INSERM U.301, Hôpital Saint Louis, Paris, France.
出版信息
Br J Haematol. 1987 Sep;67(1):51-4. doi: 10.1111/j.1365-2141.1987.tb02295.x.
We have investigated two chronic myeloid leukaemic (CML) patients with a stable Ph1 mosaicism to see whether the Ph1 positive cells belonged to more than one lineage. Individual erythroid and granulocytic colonies were cytogenetically examined. Ph1-positive and Ph1-negative colonies were found both in the erythroid and granulocytic lineage supporting the contention that CML with a stable Ph1 mosaicism as well as classical CML involves a pluripotent stem cell.
我们研究了两名慢性粒细胞白血病（CML）患者，其Ph1染色体嵌合体稳定，以观察Ph1阳性细胞是否属于多个谱系。对单个红系和粒系集落进行了细胞遗传学检查。在红系和粒系谱系中均发现了Ph1阳性和Ph1阴性集落，这支持了以下观点：具有稳定Ph1染色体嵌合体的CML以及经典CML均涉及一个多能干细胞。
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