Kim Dong Ik, Yoon Chang Ki, Yu Hyeong Gon
From the Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
From the Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
Am J Ophthalmol. 2022 May;237:204-210. doi: 10.1016/j.ajo.2021.10.033. Epub 2021 Nov 13.
To investigate the association between the presence of a cilioretinal artery (CRA) and advanced age-related macular degeneration (AMD), including the prevalence of choroidal neovascularization (CNV) and geographic atrophy (GA).
Retrospective cross-sectional study.
This was a single-center study. A total of 738 patients with AMD who underwent optical coherence tomography angiography (OCTA) were included in the study. Fundus photographs were reviewed to determine the presence of the CRA. In patients with a unilateral CRA, paired tests were performed between eyes with and without the CRA to compare AMD severity and prevalence of CNV and GA. The main outcomes of interest were AMD stage and prevalence of CNV and GA. Macular vasculature, including vessel density, perfusion density, and foveal avascular zone, were examined using OCTA.
A total of 174 eyes from 87 patients with a unilateral CRA were examined. A total of 27.8% and 8.1% of patients had a CRA in 1 eye and both eyes, respectively. Eyes with a CRA showed lower AMD stage (4-step AREDS category; P = .037) and a lower prevalence of CNV (23.0% vs 41.4%; P = .024) than those without a CRA. The prevalence of GA and macular vessel density, perfusion density, and foveal avascular zone measured by OCTA were similar in both groups.
In the eyes with a CRA, AMD stage and prevalence of CNV were lower than those in the eyes without a CRA. However, the effect of the CRA on the macular vascular system remains unclear.
研究睫状视网膜动脉（CRA）的存在与晚期年龄相关性黄斑变性（AMD）之间的关联，包括脉络膜新生血管（CNV）和地图样萎缩（GA）的患病率。
回顾性横断面研究。
这是一项单中心研究。共有738例接受光学相干断层扫描血管造影（OCTA）的AMD患者纳入本研究。通过眼底照片评估CRA的存在情况。对于单侧CRA的患者，对有CRA和无CRA的眼进行配对检测，以比较AMD严重程度以及CNV和GA的患病率。主要观察指标为AMD分期以及CNV和GA的患病率。使用OCTA检查黄斑血管系统，包括血管密度、灌注密度和黄斑无血管区。
共检查了87例单侧CRA患者的174只眼。分别有27.8%和8.1%的患者单眼和双眼存在CRA。与无CRA的眼相比，有CRA的眼AMD分期较低（4级年龄相关性眼病研究分类；P = 0.037），CNV患病率较低（23.0%对41.4%；P = 0.024）。两组间GA患病率以及通过OCTA测量的黄斑血管密度、灌注密度和黄斑无血管区相似。
有CRA的眼中，AMD分期和CNV患病率低于无CRA的眼。然而，CRA对黄斑血管系统的影响仍不清楚。
