Bai Xuelian, Liu Bo, Wu Yun, Wu Chunyan, Zhao Lifeng, Wang Lijun, Yang Haixiang
Department of Oncology, Baotou Central Hospital Baotou 014040, China.
Am J Transl Res. 2021 Oct 15;13(10):11875-11882. eCollection 2021.
Cervical cancer is a malignant tumor commonly found in women. This study was conducted to discuss the differential expression of carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCCA) in patients with advanced cervical cancer undergoing various chemotherapies and their effects on patient safety.
A total of 65 patients admitted to our hospital with advanced cervical cancer were included as the study subjects and were divided into two groups based on the chemotherapy they received: control group (n = 31) and observation group (n = 34). After two cycles of systemic (IV) chemotherapy in the control group and intra-arterial infusion chemotherapy in the observation group, the two groups were compared for treatment efficacy.
After chemotherapy, the effective rate was 76.47% in the observation group and 48.39% in the control group ( < 0.05). The CEA and SCCA levels were reduced in the two groups, and the observation group had significantly lower levels than the control group ( < 0.05), and also in patients with CR and PR ( < 0.05).
In patients with advanced cervical cancer, intra-arterial infusion chemotherapy can improve the efficacy and short-and long-term survival, and reduce the serum VEGF level, blood flow in the tumor, metastasis, and reoccurrence.
宫颈癌是女性常见的恶性肿瘤。本研究旨在探讨晚期宫颈癌患者在接受不同化疗时癌胚抗原（CEA）和鳞状细胞癌抗原（SCCA）的差异表达及其对患者安全性的影响。
选取我院收治的65例晚期宫颈癌患者作为研究对象，根据接受的化疗方案分为两组：对照组（n = 31）和观察组（n = 34）。对照组进行两个周期的全身（静脉）化疗，观察组进行动脉内灌注化疗，比较两组的治疗效果。
化疗后，观察组有效率为76.47%，对照组为48.39%（<0.05）。两组CEA和SCCA水平均降低，观察组水平显著低于对照组（<0.05），CR和PR患者中也是如此（<0.05）。
对于晚期宫颈癌患者，动脉内灌注化疗可提高疗效及短期和长期生存率，并降低血清VEGF水平、肿瘤血流、转移和复发。
