Hu Yan-Lan, Ding Tao
Hanchuan People's Hospital Hanchuan 431600, Hubei, China.
Am J Transl Res. 2021 Oct 15;13(10):11999-12005. eCollection 2021.
In this study, we aim to investigate if there exists some change in the pathogenicity of SARS-CoV-2 by comparing the clinical characteristics between recent imported patients and earlier local patients.
227 local COVID-19 patients diagnosed before February 15, 2020 (local group) and 23 imported COVID-19 patients diagnosed between July 1, 2020, and January 15, 2021 (imported group) were included in this study. Baseline characteristics and characteristics of computed tomography (CT), routine blood test, liver functions, and infectious markers upon admission were collected and compared.
The neutrophil-to-lymphocyte ratio (NLR) of the imported group was 3.21 ± 1.25, which was significantly higher than that of the local group (2.55 ± 1.19) with a -value of 0.030. The concentration of C-reactive protein of the imported group was 12.34 ± 5.25, which was significantly higher than that of the local group (7.76 ± 6.54 mg/L) with a -value of 0.0005. No significant difference was observed in the rest characteristics.
The recent imported cases had higher NLR and C-reactive protein levels than the earlier local cases, indicating that the pathogenicity of SARS-CoV-2 is getting worse during the pandemic.
在本研究中，我们旨在通过比较近期输入病例和早期本地病例的临床特征，调查新型冠状病毒（SARS-CoV-2）的致病性是否存在某些变化。
本研究纳入了2020年2月15日前确诊的227例本地新冠肺炎患者（本地组）和2020年7月1日至2021年1月15日期间确诊的23例输入性新冠肺炎患者（输入组）。收集并比较入院时的基线特征、计算机断层扫描（CT）特征、血常规、肝功能和感染指标。
输入组的中性粒细胞与淋巴细胞比值（NLR）为3.21±1.25，显著高于本地组（2.55±1.19），P值为0.030。输入组的C反应蛋白浓度为12.34±5.25，显著高于本地组（7.76±6.54mg/L），P值为0.0005。其余特征未观察到显著差异。
近期输入病例的NLR和C反应蛋白水平高于早期本地病例，表明在疫情期间SARS-CoV-2的致病性正在恶化。
