Zhu Ming-Hui, Nie Chang-Fu
Department of General Surgery, Zhengzhou People's Hospital, Zhengzhou 450008, Henan Province, China.
Department of Hepatopancreatobiliary Surgery, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
World J Clin Cases. 2021 Oct 26;9(30):9101-9107. doi: 10.12998/wjcc.v9.i30.9101.
Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. The first case of pancreatic GCT was described in 1975, and up to now, only 7 cases have been reported.
A 53-year-old male had a pancreatic mass for 1 mo. He was not treated at the local hospital, but referred to Henan Tumor Hospital for surgery. Preoperative imaging revealed a 2.0 cm × 2.5 cm-sized mass located in the body of the pancreas. At the microscopic level, a large number of eosinophilic particles are present in the oval tumor cells. The immunohistochemistry of this tumor cell display CD56 (+), blood vessels CD34 (+), Ki-67 (+) < 10%, and S-100 (+).
GCT of the pancreas should be recognized as a preoperative differential diagnosis of pancreatic tumors. Surgical resection of the tumor should be attempted; however, GCT of the pancreas has a certain rate of tumor metastasis and recurrence. Therefore, GCT of the pancreas requires regular and long-term follow-up.
胰腺颗粒细胞瘤（GCT）是一种罕见的神经源性肿瘤。1975年首次报道了胰腺GCT病例，截至目前，仅报告了7例。
一名53岁男性有胰腺肿物1个月。他未在当地医院接受治疗，而是转诊至河南省肿瘤医院进行手术。术前影像学检查显示，胰腺体部有一个大小为2.0 cm×2.5 cm的肿物。在显微镜下，椭圆形肿瘤细胞内存在大量嗜酸性颗粒。该肿瘤细胞的免疫组化显示CD56（+）、血管CD34（+）、Ki-67（+）<10%，且S-100（+）。
胰腺GCT应作为胰腺肿瘤术前鉴别诊断予以认识。应尝试手术切除肿瘤；然而，胰腺GCT有一定的肿瘤转移和复发率。因此，胰腺GCT需要定期和长期随访。
