Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA.
Ann Diagn Pathol. 2010 Dec;14(6):457-60. doi: 10.1016/j.anndiagpath.2009.10.010. Epub 2010 Feb 11.
We report an unusual case of metastatic adult granulosa cell tumor in the head of pancreas mimicking a benign pancreatic cyst in a 43-year-old female. Clinically, it was considered a benign cyst of the pancreas based on its appearance by imaging and that repeated fine-needle aspiration and cytologic examination of cystic fluid failed to identify malignant cells. The cyst in her pancreas grew slowly during the 15 months of close follow-up. Subsequent drainage and open biopsy of the cyst wall established the diagnosis of metastatic adult granulosa cell tumor that was confirmed in pancreaticoduodenectomy specimen. Immunohistochemical study and clinical history were critical to make the correct diagnosis and to differentiate this tumor from other more commonly encountered cystic neoplasms of the pancreas.
我们报告了一例 43 岁女性胰腺头部转移性成人颗粒细胞瘤的罕见病例，该肿瘤表现为良性胰腺囊肿。临床上，根据其影像学表现以及反复进行的细针抽吸和囊液细胞学检查未能发现恶性细胞，该病例被认为是良性胰腺囊肿。在密切随访的 15 个月中，她胰腺中的囊肿生长缓慢。随后对囊肿壁进行引流和开放性活检，确立了转移性成人颗粒细胞瘤的诊断，该诊断在胰十二指肠切除术标本中得到了证实。免疫组织化学研究和临床病史对于做出正确诊断以及将该肿瘤与胰腺其他更常见的囊性肿瘤区分开来至关重要。
