Hospital São José de Doenças Infecciosas, Fortaleza, CE, Brasil.
Secretaria de Saúde do Estado do Ceará, Fortaleza, CE, Brasil.
Rev Soc Bras Med Trop. 2021 Nov 12;54:e0383. doi: 10.1590/0037-8682-0383-2021. eCollection 2021.
In this study, we report the occurrence of multisystemic inflammatory syndrome among 64 children (2 deaths) with recent severe acute respiratory syndrome-related coronavirus 2 (SARS-COV-2) infections in the northeast region of Brazil. The major clinical symptoms and signs reported were exanthema (60.9%), abdominal pain (56.3%), nausea and vomiting (46.9%), diarrhea (37.5%), and dyspnea (37.5%). Laboratory findings revealed that the levels of C-reactive protein (75.0%), hemoglobin (51.6%), D-dimer (48.4%), lymphocytes (43.8%), LDH (45.3%), AST (42.2%), ALT (51.6%), and ferritin (48.4%) were above the reference values for a given age and gender. The clinical findings were similar to those observed in Kawasaki disease, although it represents a separate entity, emphasizing the need for proactive surveillance and early treatment.
在这项研究中，我们报告了巴西东北部地区 64 例（2 例死亡）近期严重急性呼吸综合征相关冠状病毒 2（SARS-CoV-2）感染儿童发生的多系统炎症综合征。报告的主要临床症状和体征包括出疹（60.9%）、腹痛（56.3%）、恶心和呕吐（46.9%）、腹泻（37.5%）和呼吸困难（37.5%）。实验室检查发现 C 反应蛋白（75.0%）、血红蛋白（51.6%）、D-二聚体（48.4%）、淋巴细胞（43.8%）、乳酸脱氢酶（45.3%）、天冬氨酸氨基转移酶（42.2%）、丙氨酸氨基转移酶（51.6%）和铁蛋白（48.4%）水平均高于特定年龄和性别的参考值。临床发现与川崎病相似，但它是一种独立的实体，强调需要主动监测和早期治疗。
