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便携式即时诊断设备:最新综述。

Portable point-of-care diagnostic devices: an updated review.

作者信息

Shu Tong, Hunter Haley, Zhou Ziping, Sun Yanping, Cheng Xiaojun, Ma Jianxin, Su Lei, Zhang Xueji, Serpe Michael J

机构信息

Research Center for Biosensor and Nanotheranostic, Shenzhen Key Laboratory for Nano-Biosensing Technology, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, P. R. China.

Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China.

出版信息

Anal Methods. 2021 Nov 25;13(45):5418-5435. doi: 10.1039/d1ay01643a.

Abstract

The global pandemic caused by the SARS-CoV-2 (COVID) virus indiscriminately impacted people worldwide with unquantifiable and severe impacts on all aspects of our lives, regardless of socioeconomic status. The pandemic brought to light the very real possibility of pathogens changing and shaping the way we live, and our lack of preparedness to deal with viral/bacterial outbreaks. Importantly, the quick detection of pathogens can help prevent and control the spread of disease, making the importance of diagnostic techniques undeniable. Point-of-care diagnostics started as a supplement to standard lab-based diagnostics, and are gradually becoming mainstream. Because of this, and their importance in detecting pathogens (especially in the developing world), their development has accelerated at an unprecedented rate. In this review, we highlight some important and recent examples of point-of-care diagnostics for detecting nucleic acids, proteins, bacteria, and other biomarkers, with the intent of making apparent their positive impact on society and human health.

摘要

由严重急性呼吸综合征冠状病毒2(COVID)引发的全球大流行,不分青红皂白地影响了世界各地的人们,对我们生活的方方面面都产生了无法估量的严重影响,无论社会经济地位如何。这场大流行揭示了病原体改变和塑造我们生活方式的切实可能性,以及我们应对病毒/细菌爆发的准备不足。重要的是,病原体的快速检测有助于预防和控制疾病传播,这使得诊断技术的重要性不可否认。即时检测诊断最初是作为基于标准实验室诊断的补充,现在正逐渐成为主流。正因如此,以及它们在检测病原体方面的重要性(尤其是在发展中世界),它们以前所未有的速度加速发展。在这篇综述中,我们重点介绍了一些用于检测核酸、蛋白质、细菌和其他生物标志物的即时检测诊断的重要且最新的例子,旨在彰显它们对社会和人类健康的积极影响。

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