The Hamlyn Centre, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Sensors (Basel). 2024 May 22;24(11):3294. doi: 10.3390/s24113294.
Cerebrospinal fluid (CSF) is a body fluid that can be used for the diagnosis of various diseases. However, CSF collection requires an invasive and painful procedure called a lumbar puncture (LP). This procedure is applied to any patient with a known risk of central nervous system (CNS) damage or neurodegenerative disease, regardless of their age range. Hence, this can be a very painful procedure, especially in infants and elderly patients. On the other hand, the detection of disease biomarkers in CSF makes diagnoses as accurate as possible. This review aims to explore novel electrochemical biosensing platforms that have impacted biomedical science. Biosensors have emerged as techniques to accelerate the detection of known biomarkers in body fluids such as CSF. Biosensors can be designed and modified in various ways and shapes according to their ultimate applications to detect and quantify biomarkers of interest. This process can also significantly influence the detection and diagnosis of CSF. Hence, it is important to understand the role of this technology in the rapidly progressing field of biomedical science.
脑脊液（CSF）是一种可用于诊断各种疾病的体液。然而，CSF 的采集需要一种称为腰椎穿刺（LP）的侵入性和有创性程序。该程序适用于任何已知有中枢神经系统（CNS）损伤或神经退行性疾病风险的患者，无论其年龄范围如何。因此，这可能是一个非常痛苦的过程，尤其是在婴儿和老年患者中。另一方面，CSF 中疾病生物标志物的检测可使诊断尽可能准确。本综述旨在探讨对生物医学科学产生影响的新型电化学生物传感平台。生物传感器已成为加速检测体液（如 CSF）中已知生物标志物的技术。生物传感器可以根据其最终应用以各种方式和形状进行设计和修改，以检测和定量感兴趣的生物标志物。这个过程也可以极大地影响 CSF 的检测和诊断。因此，了解该技术在快速发展的生物医学科学领域中的作用非常重要。
