美国犬类巴尔通体血清流行病学及与临床病理结果的关系。
Bartonella spp. seroepidemiology and associations with clinicopathologic findings in dogs in the United States.
机构信息
Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
出版信息
J Vet Intern Med. 2022 Jan;36(1):116-125. doi: 10.1111/jvim.16311. Epub 2021 Nov 17.
BACKGROUND
Improved understanding of Bartonella spp. serology in dogs may aid clinical decision making.
OBJECTIVE
Describe demographic and geographic patterns of Bartonella spp. seroreactivity in dogs, and describe hematologic and serum biochemical abnormalities in Bartonella spp. seroreactive and nonseroreactive dogs.
ANIMALS
Serum samples from 5957 dogs in the United States, previously submitted to IDEXX Reference Laboratories.
METHODS
Serum was tested using 3 indirect ELISAs for B. henselae, B. vinsonii subsp. berkhoffii, and B. koehlerae. Complete blood count and serum biochemistry panel results were reviewed retrospectively.
RESULTS
Overall, 6.1% of dogs were Bartonella spp. seroreactive. Toy breeds were less likely to be seroreactive (3.9%) than mixed breeds (7.5%; adjusted odds ratio [aOR], 0.48; 95% confidence interval [CI], 0.32-0.72), and dogs <1 year old were less likely to be seroreactive (3.4%) than dogs 1 to 5.5 years of age (7.3%; aOR, 0.42; 95% CI, 0.23-0.72). Dogs in the West South Central (9.8%) and South Atlantic (8.8%) regions were more likely than dogs elsewhere in the United States to be seroreactive (aOR, 2.22; 95% CI, 1.31-3.87; aOR, 2.44; 95% CI, 1.38-4.36).
CONCLUSIONS AND CLINICAL IMPORTANCE
Demographic and geographic findings for Bartonella spp. exposure were broadly comparable to previously reported patterns.
背景
提高对犬贝氏巴尔通体属血清学的认识可能有助于临床决策。
目的
描述犬贝氏巴尔通体属血清学反应的人口统计学和地理模式，并描述贝氏巴尔通体属血清学反应和非血清学反应犬的血液学和血清生化异常。
动物
来自美国的 5957 只犬的血清样本，先前提交给 IDEXX 参考实验室。
方法
使用 3 种间接酶联免疫吸附试验检测血清中的 B. henselae、B. vinsonii subsp. berkhoffii 和 B. koehlerae。回顾性审查全血细胞计数和血清生化小组结果。
结果
总体而言，6.1%的犬为贝氏巴尔通体属血清学反应阳性。玩具品种犬（3.9%）比混合品种犬（7.5%；调整后的优势比[aOR]，0.48；95%置信区间[CI]，0.32-0.72）更不易发生血清学反应，1 岁以下的犬（3.4%）比 1 至 5.5 岁的犬（7.3%；aOR，0.42；95% CI，0.23-0.72）更不易发生血清学反应。美国西部中南部（9.8%）和大西洋南部（8.8%）地区的犬比美国其他地区的犬更有可能发生血清学反应（aOR，2.22；95% CI，1.31-3.87；aOR，2.44；95% CI，1.38-4.36）。
结论和临床意义
贝氏巴尔通体属暴露的人口统计学和地理发现与先前报道的模式大致相似。
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