Swargiary Ananta, Roy Mritunjoy Kumar, Verma Akalesh Kumar
Department of Zoology, Bodoland University, Kokrajhar, Assam, 783370 India.
Department of Zoology, Cotton University, Guwahati, Assam, 781001 India.
J Parasit Dis. 2021 Dec;45(4):1123-1134. doi: 10.1007/s12639-021-01410-0. Epub 2021 Jun 15.
, , , and are important folk medicinal plants used by tribal communities of Bodoland region of Assam to treat helminth infections. Because of their ethnomedicinal values, the present study was designed to investigate the antioxidant, antiproliferative, and anthelmintic activities of the plants. The antioxidant activity was measured by total antioxidant capacity, total phenolics (TPC), total flavonoid (TFC), FRAP, DPPH, ABTS, and TBARS assay. Antiproliferative and apoptosis-inducing activities of plants were conducted in Dalton's lymphoma (DL) cells. Cells were treated for 24 h with different doses (25-200 mg/mL) of plant extracts. Anthelmintic study was conducted by treating the sp. at different doses of plant extracts. Phytochemical and antioxidant studies showed rich TPC, TFC, and free radical scavenging activity in and . Both the antiproliferative and anthelmintic bioassays showed a dose-dependent efficacy in all plants. showed the strongest anthelmintic activity (LC 0.21 mg/mL) followed by (5.36 mg/mL), (13.40 mg/mL), and (18.40 mg/mL). Evidently, showed the strongest antiproliferative and apoptosis-inducing activities among all the plants. The study observed a positive correlation between the antioxidant properties and antiproliferative and anthelmintic activities of the plants. We, therefore, conclude that the phytocompounds present in the crude extracts along with antioxidant molecules may have combined effects contributing to the antiproliferative and anthelmintic activities of the plants.
[植物名称1]、[植物名称2]、[植物名称3]和[植物名称4]是印度阿萨姆邦博多兰地区部落社区用于治疗蠕虫感染的重要民间药用植物。由于它们的民族药用价值，本研究旨在调查这些植物的抗氧化、抗增殖和驱虫活性。通过总抗氧化能力、总酚含量（TPC）、总黄酮含量（TFC）、铁还原抗氧化能力（FRAP）、1,1-二苯基-2-苦基肼自由基（DPPH）、2,2'-联氮-双-3-乙基苯并噻唑啉-6-磺酸（ABTS）和硫代巴比妥酸反应物（TBARS）测定来测量抗氧化活性。在道尔顿淋巴瘤（DL）细胞中进行植物的抗增殖和诱导凋亡活性研究。用不同剂量（25 - 200mg/mL）的植物提取物处理细胞24小时。通过用不同剂量的植物提取物处理[蠕虫种类]进行驱虫研究。植物化学和抗氧化研究表明，[植物名称1]和[植物名称2]中富含TPC、TFC和自由基清除活性。抗增殖和驱虫生物测定在所有植物中均显示出剂量依赖性疗效。[植物名称1]显示出最强的驱虫活性（半数致死浓度为0.21mg/mL），其次是[植物名称2]（5.36mg/mL）、[植物名称3]（13.40mg/mL）和[植物名称4]（18.40mg/mL）。显然，[植物名称1]在所有植物中显示出最强的抗增殖和诱导凋亡活性。该研究观察到植物的抗氧化特性与抗增殖和驱虫活性之间存在正相关。因此，我们得出结论，粗提物中存在的植物化合物与抗氧化分子可能具有协同作用，有助于植物的抗增殖和驱虫活性。
