Department of Rehabilitation Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Int J Med Sci. 2021 Sep 9;18(16):3644-3651. doi: 10.7150/ijms.46834. eCollection 2021.
Emerging evidence suggests that immune-inflammatory processes are key elements in the physiopathological events associated with traumatic brain injury (TBI). TBI is followed by T-cell-specific immunological changes involving several subsets of T-helper cells and the cytokines they produce; these processes can have opposite effects depending on the disease course and cytokine concentrations. Efforts are underway to identify the T-helper cells and cytokine profiles associated with prognosis. These predictors may eventually serve as effective treatment targets to decrease morbidity and mortality and to improve the management of TBI patients. Here, we review the immunological response to TBI, the possible molecular mechanisms of this response, and therapeutic strategies to address it.
新出现的证据表明，免疫炎症过程是与创伤性脑损伤（TBI）相关的生理病理事件的关键因素。TBI 后会发生 T 细胞特异性免疫变化，涉及几种辅助性 T 细胞亚群及其产生的细胞因子；这些过程的影响取决于疾病进程和细胞因子浓度，可能相反。目前正在努力确定与预后相关的辅助性 T 细胞和细胞因子谱。这些预测因子最终可能成为有效的治疗靶点，以降低发病率和死亡率，并改善 TBI 患者的管理。在这里，我们回顾了 TBI 的免疫反应、这种反应的可能分子机制以及解决它的治疗策略。
