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I至III期非小细胞肺癌中起源于左上肺不同节段的肿瘤患者的生存率。

Survival rates of patients with tumors originating in different segments of the left upper lung in stage I to III non-small cell lung cancer.

作者信息

Xiao Yi, Luo Shaoning, He Jinyuan, Zhou Yubin, Li Wei, Lan Jun, Yang Xiongwen, Huang Shaohong

机构信息

Department of Thoracocardiac Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Department of Emergency Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

出版信息

Ann Transl Med. 2021 Oct;9(20):1590. doi: 10.21037/atm-21-5157.

DOI:10.21037/atm-21-5157
PMID:34790796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8576706/
Abstract

BACKGROUND

The aim of this research was to evaluate the effect of spatial location of tumors on the prognosis of patients with left upper lung non-small cell lung cancer (NSCLC), with a focus on the S1+2+3 and lingual segment.

METHODS

A total of 486 patients who underwent lobectomy and systematic lymph node dissection were collected retrospectively in this study (354 S1+2+3 and 132 lingual segment patients). Factors impacting survival were assessed via univariate analyses, multivariate analyses, and log-rank tests.

RESULTS

Compared with tumor location in S1+2+3, lingual segment tumor location of stage II to III left upper lung NSCLC patients was significantly associated with a better 5-year disease-free survival (DFS) (P=0.041). Multivariate analysis results showed that tumor location in the lingual segment was a good independent prognostic factor of stage II to III left upper lung NSCLC patients [hazard ratio (HR) =0.602, 95% confidence interval (CI): 0.149-0.865, P=0.006). However, in stage I left upper lung NSCLC, tumor location (HR =1.069, 95% CI: 0.571-2.000, P=0.835) was not an independent prognostic factor, and only T2 (HR =2.422, 95% CI: 1.271-4.620, P=0.007) was an independent worse prognosis factor.

CONCLUSIONS

Tumor location in the lingual segment of left upper lung stage II to stage III NSCLC is a good independent prognostic factor compared with S1+2+3. Nevertheless, tumor location does not impact the prognosis of patients with stage I NSCLC in the left upper lung.

摘要

背景

本研究旨在评估肿瘤的空间位置对左上肺非小细胞肺癌（NSCLC）患者预后的影响，重点关注S1+2+3和舌段。

方法

本研究回顾性收集了486例行肺叶切除术和系统性淋巴结清扫术的患者（354例S1+2+3患者和132例舌段患者）。通过单因素分析、多因素分析和对数秩检验评估影响生存的因素。

结果

与肿瘤位于S1+2+3相比，II至III期左上肺NSCLC患者的舌段肿瘤位置与更好的5年无病生存率（DFS）显著相关（P=0.041）。多因素分析结果显示，舌段肿瘤位置是II至III期左上肺NSCLC患者良好的独立预后因素[风险比（HR）=0.602，95%置信区间（CI）：0.149-0.865，P=0.006]。然而，在I期左上肺NSCLC中，肿瘤位置（HR =1.069，95%CI：0.571-2.000，P=0.835）不是独立的预后因素，只有T2（HR =2.422，95%CI：1.271-4.620，P=0.007）是独立的不良预后因素。

结论

与S1+2+3相比，左上肺II至III期NSCLC舌段的肿瘤位置是良好的独立预后因素。然而，肿瘤位置并不影响左上肺I期NSCLC患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/5b9007852432/atm-09-20-1590-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/5c26d597fbb4/atm-09-20-1590-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/d06bdabbddab/atm-09-20-1590-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/b7c5f0c417bc/atm-09-20-1590-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/c64d388260b2/atm-09-20-1590-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/7fdd05405ee0/atm-09-20-1590-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/5b9007852432/atm-09-20-1590-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/5c26d597fbb4/atm-09-20-1590-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/d06bdabbddab/atm-09-20-1590-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/b7c5f0c417bc/atm-09-20-1590-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/c64d388260b2/atm-09-20-1590-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/7fdd05405ee0/atm-09-20-1590-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f7/8576706/5b9007852432/atm-09-20-1590-f6.jpg

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