Xu Hui, Yu Shaobin, Peng Kaiming, Gao Lei, Chen Sui, Shen Zhimin, Han Ziyang, Chen Mingduan, Lin Jihong, Chen Shuchen, Kang Mingqiang
Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Science, Fujian Medical University, Fuzhou, China.
Ann Transl Med. 2021 Oct;9(20):1600. doi: 10.21037/atm-21-5025.
The purpose of this paper was to investigate the role and mechanism of EEF1D in various diseases, especially in tumorigenesis and development, and explore the possibility of EEF1D as a biological target.
EEF1D is a part of the EEF1 protein complex, which can produce four protein isoforms, of which three short isoforms are used as translation elongation factors. The three short isoforms play a role in anti-aging, regulating the cell cycle, and promoting the occurrence and development of malignant tumors, and the only long-form isoform plays a role in the development of the nervous system.
We searched the PubMed and Web of Science databases for literature up to January 2021 using relevant keywords, including "EEF1D", "eukaryotic translation elongation factor 1 delta", "translation elongation factor", "translation elongation factor and cancer", and "translation elongation factor and nervous system disease". We then created an overview of the literature and summarized the results of the paper.
Through the review of relevant articles, we found that EEF1D is obviously overexpressed in a variety of tumors, and can regulate the proliferation of tumor cells and tumor growth, as well as play a role in tumor invasion. EEF1D is likely to become a new biological target for tumor therapy and diagnosis.
本文旨在研究EEF1D在各种疾病中的作用及机制，尤其是在肿瘤发生和发展中的作用，并探索EEF1D作为生物学靶点的可能性。
EEF1D是EEF1蛋白复合体的一部分，它能产生四种蛋白质异构体，其中三种短异构体用作翻译延伸因子。这三种短异构体在抗衰老、调节细胞周期以及促进恶性肿瘤的发生和发展中发挥作用，而唯一的长异构体在神经系统发育中发挥作用。
我们使用相关关键词，包括“EEF1D”、“真核翻译延伸因子1δ”、“翻译延伸因子”、“翻译延伸因子与癌症”以及“翻译延伸因子与神经系统疾病”，在PubMed和Web of Science数据库中检索截至2021年1月的文献。然后我们对文献进行了综述并总结了本文的结果。
通过对相关文章的综述，我们发现EEF1D在多种肿瘤中明显过表达，并且可以调节肿瘤细胞的增殖和肿瘤生长，以及在肿瘤侵袭中发挥作用。EEF1D很可能成为肿瘤治疗和诊断的新生物学靶点。
