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关于在肝细胞癌中与EEF1复合蛋白具有相似表达模式的基因的数据文章。

Data article on genes that share similar expression patterns with EEF1 complex proteins in hepatocellular carcinoma.

作者信息

Biterge Süt Burcu

机构信息

Niğde Ömer Halisdemir University, Faculty of Medicine, Department of Medical Biology, Turkey.

出版信息

Data Brief. 2020 Jan 23;29:105162. doi: 10.1016/j.dib.2020.105162. eCollection 2020 Apr.

DOI:10.1016/j.dib.2020.105162
PMID:32025546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6997806/
Abstract

Eukaryotic Elongation Factor complex 1 (EEF1) consists of six subunits namely EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1E1 and EEF1G. Recently we showed that EEF1 complex proteins might play critical roles in cancer [1]. This article provides data on genes that share similar expression patterns with EEF1 complex proteins in cancer by analyzing RNA expression data using GEPIA online tool. Correlation analysis was performed on selected genes in a pairwise manner and the Pearson coefficients were automatically calculated by the GEPIA online tool. These data can be useful for future studies directed towards understanding the mechanisms by which EEF1 complex proteins affect in cancer pathogenesis.

摘要

真核延伸因子复合物1(EEF1)由六个亚基组成,即EEF1A1、EEF1A2、EEF1B2、EEF1D、EEF1E1和EEF1G。最近我们发现EEF1复合蛋白可能在癌症中发挥关键作用[1]。本文通过使用GEPIA在线工具分析RNA表达数据,提供了与癌症中EEF1复合蛋白具有相似表达模式的基因的数据。对选定基因进行两两相关分析,GEPIA在线工具自动计算皮尔逊系数。这些数据可能有助于未来旨在了解EEF1复合蛋白影响癌症发病机制的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d31/6997806/8d025a0fb36d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d31/6997806/8d025a0fb36d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d31/6997806/8d025a0fb36d/gr1.jpg

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Data Brief. 2020 Jan 23;29:105162. doi: 10.1016/j.dib.2020.105162. eCollection 2020 Apr.
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本文引用的文献

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Alterations in Eukaryotic Elongation Factor complex proteins (EEF1s) in cancer and their implications in epigenetic regulation.真核延伸因子复合物蛋白(EEF1s)在癌症中的改变及其在表观遗传调控中的意义。
Life Sci. 2019 Dec 1;238:116977. doi: 10.1016/j.lfs.2019.116977. Epub 2019 Oct 19.
2
Oncogenic Signaling Pathways in The Cancer Genome Atlas.癌症基因组图谱中的致癌信号通路。
Cell. 2018 Apr 5;173(2):321-337.e10. doi: 10.1016/j.cell.2018.03.035.
3
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
蛋白质合成因子eIFs、eEFs和eRFs在炎症性肠病和结直肠癌发病机制中的研究进展。
Front Oncol. 2022 Oct 31;12:898966. doi: 10.3389/fonc.2022.898966. eCollection 2022.
4
The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases.真核生物翻译延伸因子(EEFs)的假基因:在癌症和其他人类疾病中的作用。
Genes Dis. 2021 Apr 16;9(4):941-958. doi: 10.1016/j.gendis.2021.03.009. eCollection 2022 Jul.
5
Interfering with the expression of EEF1D gene enhances the sensitivity of ovarian cancer cells to cisplatin.干扰 EEF1D 基因的表达可增强卵巢癌细胞对顺铂的敏感性。
BMC Cancer. 2022 Jun 8;22(1):628. doi: 10.1186/s12885-022-09699-7.
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The role of EEF1D in disease pathogenesis: a narrative review.EEF1D在疾病发病机制中的作用:一篇叙述性综述。
Ann Transl Med. 2021 Oct;9(20):1600. doi: 10.21037/atm-21-5025.
起源细胞模式主导了 33 种癌症类型的 10000 个肿瘤的分子分类。
Cell. 2018 Apr 5;173(2):291-304.e6. doi: 10.1016/j.cell.2018.03.022.
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GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.GEPIA:一个用于癌症和正常基因表达谱分析及交互式分析的网络服务器。
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102. doi: 10.1093/nar/gkx247.