IL-1、NLRP3 和 COX-2 基因多态性与伊朗人群自身免疫性甲状腺疾病风险及临床特征的关联。
Association of IL-1, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population.
机构信息
Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Biomed Res Int. 2021 Nov 8;2021:7729238. doi: 10.1155/2021/7729238. eCollection 2021.
BACKGROUND
Grave's disease (GD) and Hashimoto's thyroiditis (HT) are autoimmune diseases of the thyroid gland in which genetic predisposition plays a major role in their development. Currently, the role of NLRP3 inflammasome and COX-2 has been documented in many autoimmune diseases. The purpose of the study is to delineate the impact of IL-1 (rs1143634), NLRP3 (rs3806265), and COX-2 (rs2745557) gene polymorphisms in the development of GD and HT.
METHODS
A total of 256 newly diagnosed patients with autoimmune thyroid disease (135 patients with HT and 121 GD patients) as case groups and 145 controls were included in the study.
RESULTS
Recessive and overdominant models showed a significant association between IL-1 rs1143634 SNP and HT development risk. The frequency of TT genotype and T allele of IL-1 rs1143634 SNP in the control group was significantly higher than the GD group. There was no significant association between NLRP3 rs3806265 polymorphism and HT and GD development. The frequency of GA genotype of COX-2 (rs2745557) in the control group was significantly higher than that in the HT group. There was no significant association between COX-2 rs2745557 genotypic and allelic distribution and GD development risk. The results revealed a significant relationship between some clinical features of HT and GD groups and SNPs studied.
CONCLUSION
The results manifest the significant impact of IL-1 rs1143634 and COX-2 (rs2745557) SNPs and HT development and IL-1 rs1143634 SNP on GD occurrence risk. Furthermore, a significant relationship was observed between some clinical features of HT and GD groups and studied SNPs.
背景
格雷夫斯病（GD）和桥本甲状腺炎（HT）是甲状腺自身免疫性疾病，遗传易感性在其发病机制中起主要作用。目前，NLRP3 炎性小体和 COX-2 在许多自身免疫性疾病中的作用已经得到证实。本研究旨在探讨 IL-1（rs1143634）、NLRP3（rs3806265）和 COX-2（rs2745557）基因多态性在 GD 和 HT 发病中的作用。
方法
共纳入 256 例新诊断的自身免疫性甲状腺疾病患者（HT 患者 135 例，GD 患者 121 例）作为病例组，另纳入 145 例健康对照者。
结果
隐性和超显性模型均显示 IL-1 rs1143634 SNP 与 HT 发病风险显著相关。对照组 TT 基因型和 IL-1 rs1143634 SNP T 等位基因的频率明显高于 GD 组。NLRP3 rs3806265 多态性与 HT 和 GD 发病无显著相关性。对照组 COX-2（rs2745557）GA 基因型的频率明显高于 HT 组。COX-2 rs2745557 基因型和等位基因分布与 GD 发病风险无显著相关性。结果显示 HT 和 GD 组部分临床特征与研究 SNP 之间存在显著关系。
结论
结果表明，IL-1 rs1143634 和 COX-2（rs2745557）SNP 与 HT 发病以及 IL-1 rs1143634 SNP 与 GD 发病风险显著相关。此外，HT 和 GD 组的一些临床特征与研究 SNP 之间存在显著关系。
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