Evans Ngwenah Foncham, Sanda Antoine Kada, Martin Salah, Christopher Tume, Mahamat Oumar
Laboratory of Biochemistry, Department of Biochemistry, Faculty of Science, University of Bamenda, Bamenda, Cameroon.
Laboratory of Biological Sciences, Department of Biological Sciences, Faculty of Science, University of Bamenda, Bamenda, Cameroon.
Adv Pharmacol Pharm Sci. 2021 Nov 8;2021:5893210. doi: 10.1155/2021/5893210. eCollection 2021.
Natural products have been said to show immunomodulatory and antioxidant activities. The research study was aimed to assess the immunomodulatory and free radical scavenging activities of crude polysaccharide from dry mushroom fruiting bodies of .
Hot water extract of polysaccharide extract of was prepared and tested in white albino Wister rats for its immunomodulatory activities effect on methylprednisolone-immunosuppressed animals. In addition, the radical scavenging activity of the polysaccharide was evaluated using nitrite and hydrogen peroxide.
The result of the study showed that the polysaccharide increases the phagocytic index, energy metabolism of macrophages, spleen index, and nitric oxide in a concentration-dependent manner in immunosuppressed animals. Also, it was observed that the extract increased dose-dependent total oxidative stress and thymus index. Finally, the crude polysaccharide-rich extract showed nitrite and hydrogen peroxide scavenging activity in a concentration-dependent manner.
Polysaccharide-rich extract possesses immunomodulatory and antioxidant properties.
天然产物据说具有免疫调节和抗氧化活性。本研究旨在评估干蘑菇子实体粗多糖的免疫调节和自由基清除活性。
制备了多糖提取物的热水提取物，并在白化Wistar大鼠中测试其对甲基强的松龙免疫抑制动物的免疫调节活性作用。此外，使用亚硝酸盐和过氧化氢评估多糖的自由基清除活性。
研究结果表明，在免疫抑制动物中，该多糖以浓度依赖的方式增加吞噬指数、巨噬细胞能量代谢、脾脏指数和一氧化氮。此外，观察到提取物剂量依赖性地增加总氧化应激和胸腺指数。最后，富含粗多糖的提取物以浓度依赖的方式表现出亚硝酸盐和过氧化氢清除活性。
富含多糖的提取物具有免疫调节和抗氧化特性。
