V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of the Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2021 Nov;172(1):85-89. doi: 10.1007/s10517-021-05337-7. Epub 2021 Nov 18.
We performed a comparative morphological analysis of placental villi in parturient women with mild and moderate COVID-19 infection. The area and perimeter of terminal villi, their capillaries, and syncytiotrophoblast were assessed on immunohistochemical preparations with antibodies to CD31 using an image analysis system; the parameters of fetal vascular component in the placental villi were also assessed. Changes in the studied parameters differed in parturient women with mild and moderate COVID-19 infection. The observed increase in the total perimeter with a simultaneous decrease in the total capillary area and the degree of vascularization of the placental villi in parturient women with COVID-19 indicates impairment of circulation in the fetal compartment and the development of placental hypoxia, which can be the cause of unfavorable neonatal outcomes.
我们对轻度和中度 COVID-19 感染产妇的胎盘绒毛进行了比较形态学分析。使用 CD31 抗体的免疫组织化学制剂，通过图像分析系统评估了末端绒毛、毛细血管和合体滋养层的面积和周长；还评估了胎盘绒毛中胎儿血管成分的参数。在轻度和中度 COVID-19 感染的产妇中，研究参数的变化不同。在 COVID-19 产妇中，总周长增加，同时总毛细血管面积和胎盘绒毛血管化程度降低，这表明胎儿部位的循环受损和胎盘缺氧的发展，这可能是新生儿结局不佳的原因。
