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轻度或中度 COVID-19 孕妇不会影响新生儿脐带血中 CD34 造血干细胞的含量。

Mild or Moderate COVID-19 during Pregnancy Does Not Affect the Content of CD34 Hematopoietic Stem Cells in Umbilical Cord Blood of Newborns.

机构信息

CryoCenter Cord Blood Bank, Moscow, Russia.

E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2022 Aug;173(4):523-528. doi: 10.1007/s10517-022-05575-3. Epub 2022 Sep 5.

DOI:10.1007/s10517-022-05575-3
PMID:36063300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9441840/
Abstract

The study included umbilical cord blood samples (n=64) intended for cryogenic storage of hematopoietic stem cells and obtained from patients with a history of mild and moderate forms of COVID-19 during pregnancy. The control group was composed of samples (n=746) obtained from healthy women in labor. A comparative analysis of the volume of cord blood collected, the total leukocyte count, the relative and absolute content of cells with the CD34/CD45 phenotype revealed no significant differences between the groups.

摘要

本研究纳入了 64 份拟用于低温储存造血干细胞的脐带血样本，这些样本均来自妊娠期患有轻、中度 COVID-19 病史的患者。对照组由 746 份来自健康产妇的样本组成。对采集的脐带血体积、总白细胞计数、CD34/CD45 表型细胞的相对和绝对含量进行比较分析，两组间无显著差异。

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Risk factors and outcomes of cytomegalovirus infection in children post cord blood transplantation with focus on impact of graft-versus-host disease and immunosuppressants.儿童脐血移植后巨细胞病毒感染的危险因素和结果，重点关注移植物抗宿主病和免疫抑制剂的影响。
Ann Hematol. 2022 Feb;101(2):409-419. doi: 10.1007/s00277-021-04707-5. Epub 2021 Nov 2.
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The effect of coronavirus disease 2019 on newborns.新型冠状病毒病 2019 对新生儿的影响。
Curr Opin Pediatr. 2021 Dec 1;33(6):618-624. doi: 10.1097/MOP.0000000000001063.
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Early Hum Dev. 2021 Nov;162:105460. doi: 10.1016/j.earlhumdev.2021.105460. Epub 2021 Sep 1.
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