系统性红斑狼疮患者的工作参与情况：系统评价。
Work participation in patients with systematic lupus erythematosus: a systematic review.
机构信息
Department of Epidemiology and Data Science, Amsterdam Public Health, Amsterdam UMC.
Department of Rheumatology and Clinical Immunology, Amsterdam Infection & Immunity, Amsterdam UMC Location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
出版信息
Rheumatology (Oxford). 2022 Jul 6;61(7):2740-2754. doi: 10.1093/rheumatology/keab855.
OBJECTIVES
This systematic review assessed which variables are associated with or are predictors for work participation outcomes in patients with systematic lupus erythematosus (SLE).
METHODS
A literature search using MEDLINE, The Cochrane Library, Embase and CINAHL was conducted to identify all studies published from inception (1947) to June 2021 on factors related to and/or predicting employment status, absenteeism and/or presenteeism in SLE patients aged ≥18 years. The quality of included articles was assessed using the QUIPS tool. Narrative summaries were used to present the data.
RESULTS
Fifteen studies (nine on associations, four on predictions, and two assessing both) were included, encompassing data of 3800 employed patients. Younger age, Caucasian ethnicity, higher educational level, lower disease activity score, shorter disease duration, absence of specific disease manifestations, higher levels of physical functioning and less physical job demands and higher levels of psychological/cognitive functioning were associated with or predicted favorable work outcomes. Older age, non-Caucasian ethnicity, female gender, never being married, poverty, lower educational level, higher disease activity score, longer disease duration, specific disease manifestations, lower levels of physical functioning, more physical job demands and low job control, less job tenure and lower levels of cognitive functioning were associated with or predicted an unfavorable work outcome. Limitations of the evidence were the quality of the studies and the use of heterogeneous outcome measures, applied statistical methods and instruments used to assess work participation.
CONCLUSION
We recommend applying the EULAR points to consider for designing, analysing and reporting on work participation in inflammatory arthritis also to SLE studies on work participation, to enhance the quality and comparability between studies and to better understand the impact of SLE on work participation.
TRIAL REGISTRATION
registration in PROSPERO (CRD42020161275; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=161275).
目的
本系统评价评估了哪些变量与系统性红斑狼疮（SLE）患者的工作参与结果相关或可预测这些结果。
方法
使用 MEDLINE、The Cochrane Library、Embase 和 CINAHL 进行文献检索，以确定从 1947 年开始至 2021 年 6 月发表的所有关于与 SLE 患者的就业状况、缺勤和/或在职相关的因素以及/或可预测其就业状况、缺勤和/或在职的因素的研究。使用 QUIPS 工具评估纳入文章的质量。使用叙述性总结来呈现数据。
结果
纳入了 15 项研究（9 项关于关联，4 项关于预测，2 项评估两者），共纳入了 3800 名在职患者的数据。年龄较小、白种人、较高的教育水平、较低的疾病活动评分、较短的疾病病程、无特定疾病表现、较高的身体功能水平、较少的身体工作需求和较高的心理/认知功能水平与良好的工作结果相关或可预测良好的工作结果。年龄较大、非白种人、女性、从未结婚、贫困、较低的教育水平、较高的疾病活动评分、较长的疾病病程、特定的疾病表现、较低的身体功能水平、较多的身体工作需求和较低的工作控制、较短的工作任期和较低的认知功能水平与不良的工作结果相关或可预测不良的工作结果。证据的局限性在于研究的质量以及使用的异质结局测量、应用的统计方法和用于评估工作参与的工具。
结论
我们建议在设计、分析和报告炎性关节炎的工作参与以及 SLE 工作参与研究时应用 EULAR 点，以提高研究之间的质量和可比性，并更好地理解 SLE 对工作参与的影响。
试验注册
在 PROSPERO（CRD42020161275；https://www.crd.york.ac.uk/prospero/display_record.php？RecordID=161275）进行注册。
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