Institute for Cognitive and Brain Sciences, Shahid Beheshti University, G.C. Tehran, Iran.
Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
PLoS One. 2021 Nov 18;16(11):e0260091. doi: 10.1371/journal.pone.0260091. eCollection 2021.
Many studies have focused on neural changes and neuroplasticity, while the signaling demand for neural modification needs to be explored. In this study, we traced this issue in the organization of brain functional links where the conflictual arrangement of signed links makes a request to change. We introduced the number of frustrations (unsatisfied closed triadic interactions) as a measure for assessing "requirement to change" of functional brain network. We revealed that the requirement to change of the resting-state network has a u-shape functionality over the lifespan with a minimum in early adulthood, and it's correlated with the presence of negative links. Also, we discovered that brain negative subnetwork has a special topology with a log-normal degree distribution in all stages, however, its global measures are altered by adulthood. Our results highlight the study of collective behavior of functional negative links as the source of the brain's between-regions conflicts and we propose exploring the attribute of the requirement to change besides other neural change factors.
许多研究都集中在神经变化和神经可塑性上，而神经修饰的信号需求仍有待探索。在这项研究中，我们追踪了大脑功能连接组织中的这个问题，其中有符号连接的冲突排列提出了改变的要求。我们引入了挫折次数（未满足的闭合三元交互）作为评估功能网络“改变需求”的度量。我们揭示了静息态网络的改变需求在整个生命周期中呈 U 形功能，在成年早期达到最小值，并且与负性连接的存在相关。此外，我们发现大脑负子网在所有阶段都具有特殊的拓扑结构，呈对数正态度分布，但在成年期，其全局度量会发生变化。我们的研究结果强调了研究功能负性连接的集体行为作为大脑区域间冲突的来源，我们提出除了其他神经变化因素之外，还应探索改变需求的属性。
