Forno-Pizzoglio M, Cuffini A M, Carlone N A, Cavallo G P
Istituto di Microbiologia dell'Università di Torino.
G Batteriol Virol Immunol. 1986 Jan-Jun;79(1-6):154-60.
Ofloxacin, a new fluoroquinolonic synthetic compound with broad antibacterial spectrum, was used in per os therapy of 15 ear, nose and throat infected patients. The antibiotic was then compared with other eight antimicrobial agents against the Gram-positive and Gram-negative isolates. Either in vitro than in vivo the god antibacterial activity and tolerance of ofloxacin, particularly against Gram-positive infections, was demonstrated. Results point out the possibility of utilization of ofloxacin per os against ear, nose and throat infections.
氧氟沙星是一种新型的具有广谱抗菌作用的氟喹诺酮类合成化合物，用于15例耳鼻喉感染患者的口服治疗。然后将该抗生素与其他8种抗菌剂针对革兰氏阳性和革兰氏阴性分离株进行比较。结果表明，无论在体外还是体内，氧氟沙星都具有良好的抗菌活性和耐受性，尤其是对革兰氏阳性感染。结果指出了口服氧氟沙星治疗耳鼻喉感染的可能性。
