氧氟沙星治疗耳鼻咽喉感染的临床疗效。 （注：原文中of重复使用，正确的表达应该是“Clinical efficacy of ofloxacin in the treatment of otorhinolaryngological infections.” 这里按照修改后的正确内容翻译）
Clinical efficacy of ofloxacin in the treatment of otorhinolaryngological infections.
作者信息
Baba S
出版信息
Infection. 1986;14 Suppl 4:S327-31. doi: 10.1007/BF01661310.
A multi-centered clinical study was carried out to evaluate the efficacy of ofloxacin in otorhinolaryngological infections in Japan. Ofloxacin was used at a dosage of 300 mg to 800 mg daily for three to 20 days in 206 cases of various infectious diseases in the otorhinolaryngological field such as otitis media, external otitis, paranasal sinusitis, tonsillitis and pharyngolaryngitis. Its efficacy rate was 79.9%. Minor side effects were seen in three cases (1.5%), gastro-intestinal disorders in two and headache in one. The antibacterial activity of ofloxacin was compared with the activity of pipemidic acid, nalidixic acid and norfloxacin against clinically isolated microorganisms. Ofloxacin was highly superior to pipemidic acid and nalidixic acid, and slightly more active than or equivalent to norfloxacin.
在日本开展了一项多中心临床研究，以评估氧氟沙星治疗耳鼻咽喉科感染的疗效。在206例耳鼻咽喉科领域的各种传染病（如中耳炎、外耳道炎、鼻窦炎、扁桃体炎和咽喉咽炎）中，氧氟沙星的使用剂量为每日300毫克至800毫克，疗程为3至20天。其有效率为79.9%。3例（1.5%）出现轻微副作用，2例出现胃肠道不适，1例出现头痛。将氧氟沙星的抗菌活性与吡哌酸、萘啶酸和诺氟沙星对临床分离微生物的活性进行了比较。氧氟沙星比吡哌酸和萘啶酸具有高度优越性，且比诺氟沙星活性略高或相当。
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