Department of Medical Science, Shunde Polytechnic, Foshan 528333, China.
NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou 510632, China.
Fitoterapia. 2022 Jan;156:105085. doi: 10.1016/j.fitote.2021.105085. Epub 2021 Nov 16.
Four new iboga-type alkaloids, ervaoffines H-K (1-4), along with five known compounds were obtained from the aerial parts of Ervatamia officinalis. The absolute configurations of 1-4 were confirmed by X-ray diffraction and electronic circular dichroism (ECD) analyses. The isolates were tested for their anti-inflammatory activity. Compounds 1, 5, 6, and 9 showed potential inhibitory effect of NO production in LPS-stimulated BV2 and RAW264.7 cells.
从鸡骨常山（Ervatamia officinalis）的地上部分分离得到了四个新的伊波加型生物碱（1-4），以及五个已知化合物。通过 X 射线衍射和电子圆二色性（ECD）分析确定了 1-4 的绝对构型。对分离得到的化合物进行了抗炎活性测试。化合物 1、5、6 和 9 对 LPS 刺激的 BV2 和 RAW264.7 细胞中 NO 产生具有潜在的抑制作用。
