来自猪屎豆种子的黄酮类化合物、生物碱及其细胞毒性和抗炎活性。
Flavonoids, alkaloids from the seeds of Crotalaria pallida and their cytotoxicity and anti-inflammatory activities.
作者信息
Hu Xiu-Ren, Chou Gui-Xin, Zhang Cheng-Gang
机构信息
The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China; Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201203, People's Republic of China.
The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China; Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201203, People's Republic of China.
出版信息
Phytochemistry. 2017 Nov;143:64-71. doi: 10.1016/j.phytochem.2017.07.010. Epub 2017 Aug 1.
Three flavonoids, cropalliflavones A-C, including two homoisoflavonoids with rare skeletons; three previously undescribed alkaloids, usaramine-N-oxide and cropallins A-B; and sixteen known compounds, were isolated from the seeds of Crotalaria pallida Ait. The absolute configurations of cropalliflavone A and usaramine-N-oxide were established by an ECD calculation and X-ray crystallography, respectively. Additionally, cropalliflavone B showed anti-proliferative activity against the MCF-7 cell line with an IC value of 6.77 μM, and cropalliflavone C showed anti-inflammatory activity, with an IC value of 16.07 μM.
从猪屎豆（Crotalaria pallida Ait.）种子中分离出三种黄酮类化合物，即巴豆黄酮A - C，其中包括两种具有罕见骨架的高异黄酮；三种之前未被描述的生物碱，即乌沙胺 - N - 氧化物和巴豆林A - B；以及十六种已知化合物。巴豆黄酮A和乌沙胺 - N - 氧化物的绝对构型分别通过电子圆二色光谱（ECD）计算和X射线晶体学确定。此外，巴豆黄酮B对MCF - 7细胞系显示出抗增殖活性，IC值为6.77 μM，巴豆黄酮C显示出抗炎活性，IC值为16.07 μM。
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