Department of Oncology, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Br J Cancer. 2022 Mar;126(4):598-605. doi: 10.1038/s41416-021-01623-3. Epub 2021 Nov 18.
F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of F-fluciclovine in breast cancer and assessed differences in tracer kinetics and static parameters for different breast cancer receptor subtypes and tumour grades.
Thirty-nine patients with pathologically proven breast cancer underwent 20-min dynamic PET/computed tomography imaging following the administration of F-fluciclovine. Uptake into primary breast tumours was evaluated using one- and two-tissue reversible compartmental kinetic models and static parameters.
A reversible one-tissue compartment model was shown to best describe tracer uptake in breast cancer. No significant differences were seen in kinetic or static parameters for different tumour receptor subtypes or grades. Kinetic and static parameters showed a good correlation.
F-fluciclovine has potential in the imaging of primary breast cancer, but kinetic analysis may not have additional value over static measures of tracer uptake.
NCT03036943.
F-氟代脱氧鸟苷酸（F-fluciclovine）是一种合成氨基酸正电子发射断层扫描（PET）放射性示踪剂，已获批准用于前列腺癌。在这项临床研究中，我们对描述 F-氟代脱氧鸟苷酸在乳腺癌中摄取的最佳动力学模型进行了描述，并评估了不同乳腺癌受体亚型和肿瘤分级的示踪剂动力学和静态参数的差异。
39 名经病理证实患有乳腺癌的患者在注射 F-氟代脱氧鸟苷酸后进行了 20 分钟的动态 PET/CT 成像。使用单和双组织可逆转隔室动力学模型和静态参数评估原发性乳腺癌肿瘤的摄取。
结果表明，可逆单隔室模型最能描述乳腺癌中示踪剂的摄取。不同肿瘤受体亚型和分级之间，动力学和静态参数均未见明显差异。动力学和静态参数之间存在良好的相关性。
F-氟代脱氧鸟苷酸在原发性乳腺癌的成像中具有潜力，但与摄取示踪剂的静态测量相比，动力学分析可能没有额外的价值。
NCT03036943。
