Huang Chunli, Dong Changsheng, Zhu Yanan, Yu Yang, Jin Huizi, Zhang Yan
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Cancer Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2021 Nov 2;12:753128. doi: 10.3389/fphar.2021.753128. eCollection 2021.
(Franch.) Anderb, also known as Franch (), is a folk medicine of the Yi nationality in China. The Inula plants display various biological activities, including anti-nociceptive and anti-inflammatory properties. has been traditionally used for the treatment of bronchitis, vasculitis, and dizziness. However, very few studies have been reported on the pharmacology of . The present study aims to characterize the anti-nociceptive and anti-inflammatory properties of and explore the underlying mechanism. was extracted by 95% ethanol and further portioned with petroleum ether, ethyl acetate (EA) and n-butanol, sequentially, to obtain corresponding factions with different polarities. The EA fraction (IPEA) was found to be one of the most effective fractions. It demonstrated potent analgesic effects in both acute and inflammatory pain mouse models, and caused no anti-nociceptive tolerance. Furthermore, IPEA improved the tolerance of mice to morphine. IPEA also showed potent anti-inflammatory effects on LPS-induced septic mice. BIC, a GABAR antagonist, reversed the effects of IPEA in pain and inflammation models. Collectively, GABARs play a key role in the pharmacological effects of IPEA. may be useful as a complementary or alternative therapeutic agent for the treatment of pain and inflammation.
（法氏）安德伯，也称为法氏（），是中国彝族的一种民间药物。旋覆花属植物具有多种生物活性，包括抗伤害感受和抗炎特性。传统上一直用于治疗支气管炎、血管炎和头晕。然而，关于其药理学的研究报道很少。本研究旨在表征其抗伤害感受和抗炎特性，并探索其潜在机制。用95%乙醇提取，然后依次用石油醚、乙酸乙酯（EA）和正丁醇进行分配，以获得具有不同极性的相应馏分。发现乙酸乙酯馏分（IPEA）是最有效的馏分之一。它在急性和炎性疼痛小鼠模型中均显示出强效镇痛作用，且未产生抗伤害感受耐受性。此外，IPEA提高了小鼠对吗啡的耐受性。IPEA对脂多糖诱导的脓毒症小鼠也显示出强效抗炎作用。GABAR拮抗剂BIC逆转了IPEA在疼痛和炎症模型中的作用。总体而言，GABARs在IPEA的药理作用中起关键作用。可能作为治疗疼痛和炎症的补充或替代治疗剂有用。
