School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Front Immunol. 2021 Nov 2;12:762315. doi: 10.3389/fimmu.2021.762315. eCollection 2021.
Tuberculosis (TB) is a devastating infectious disease that kills over a million people every year. There is an increasing burden of multi drug resistance (MDR) and extensively drug resistance (XDR) TB. New and improved therapies are urgently needed to overcome the limitations of current treatment. The causative agent, (Mtb) is one of the most successful pathogens that can manipulate host cell environment for adaptation, evading immune defences, virulence, and pathogenesis of TB infection. Host-pathogen interaction is important to establish infection and it involves a complex set of processes. Metabolic cross talk between the host and pathogen is a facet of TB infection and has been an important topic of research where there is growing interest in developing therapies and drugs that target these interactions and metabolism of the pathogen in the host. Mtb scavenges multiple nutrient sources from the host and has adapted its metabolism to survive in the intracellular niche. Advancements in systems-based omic technologies have been successful to unravel host-pathogen interactions in TB. In this review we discuss the application and usefulness of omics in TB research that provides promising interventions for developing anti-TB therapies.
结核病（TB）是一种毁灭性的传染病，每年导致超过 100 万人死亡。耐多药（MDR）和广泛耐药（XDR）结核病的负担日益加重。迫切需要新的和改进的治疗方法来克服当前治疗的局限性。病原体， （Mtb）是最成功的病原体之一，它可以操纵宿主细胞环境以适应、逃避免疫防御、毒力和结核病感染的发病机制。宿主-病原体相互作用对于建立感染很重要，它涉及一系列复杂的过程。宿主和病原体之间的代谢串扰是结核病感染的一个方面，一直是研究的重要课题，人们越来越感兴趣的是开发针对这些相互作用和病原体在宿主中代谢的治疗方法和药物。Mtb 从宿主中掠夺多种营养来源，并调整其代谢以在细胞内环境中存活。基于系统的组学技术的进步成功地揭示了结核病中的宿主-病原体相互作用。在这篇综述中，我们讨论了组学在结核病研究中的应用和实用性，为开发抗结核病疗法提供了有希望的干预措施。
