Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Immunol. 2021 Oct 29;12:763026. doi: 10.3389/fimmu.2021.763026. eCollection 2021.
Hereditary gingival fibromatosis [HGF, (MIM 135300)], a rare benign oral condition, has several adverse consequences such as aesthetic changes, malocclusion, speech impediments, and abnormal dentition. However, relatively few studies have addressed the beneficial effects of thick gingival tissues in resisting external stimuli. In this report, we present a unique case of a family affected by HGF that manifests as a 'healthy' gingiva. Human β-defensins (hBDs) are known to play a pivotal role in the clearance and killing of various microbes, and contribute to maintaining a healthy oral environment, which is currently emerging research area. However, the expression pattern and localisation of hBDs in patients with HGF have not yet been reported. hBD-2 and hBD-3 in the pedigree we collected had relatively elevated expression. High hBD levels in the gingival tissue of patients from the family may be beneficial in protecting oral tissue from external stimuli and promoting periodontal regeneration, but their role and the mechanisms underlying HGF need to be clarified.
遗传性牙龈纤维瘤病[HGF，（MIM 135300）]是一种罕见的良性口腔疾病，有多种不良后果，如美观变化、咬合不正、言语障碍和异常牙齿。然而，相对较少的研究涉及到厚牙龈组织抵抗外部刺激的有益效果。在本报告中，我们介绍了一个独特的家族受 HGF 影响的病例，表现为“健康”的牙龈。人类β防御素（hBDs）已知在清除和杀死各种微生物方面发挥着关键作用，并有助于维持健康的口腔环境，这是当前新兴的研究领域。然而，HGF 患者 hBDs 的表达模式和定位尚未报道。我们收集的家系中 hBD-2 和 hBD-3 的表达相对升高。家族患者牙龈组织中高 hBD 水平可能有利于保护口腔组织免受外部刺激和促进牙周组织再生，但它们的作用和 HGF 的机制仍需阐明。
