Associate Professor, Department of Biochemistry named after G.Ya. Gorodisskaya; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Professor, Head of the Department of Biochemistry named after G.Ya. Gorodisskaya Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Sovrem Tekhnologii Med. 2021;12(5):114-127. doi: 10.17691/stm2020.12.5.13. Epub 2020 Oct 28.
The review is devoted to the systematization, classification, and generalization of the results of modern scientific research on the role of bile acids as a new class of steroid hormones. The paper presents the evidence for bile acid participation in the regulation of the body energy metabolism, body weight control, as well as the pathogenesis of obesity, diabetes mellitus, insulin resistance, and cardiovascular diseases. Particular attention is paid to the role of bile acids in the control of nonspecific energy expenditure of the body. The applied aspects of using the novel data about the membrane and intracellular receptors responsible for the development of hormonal regulatory effects of bile acids are analyzed. According to the authors, the modern data on the role of bile acids in the regulation of body functions allow a deeper understanding of the pathogenesis of body weight disorders and associated cardiovascular diseases. The review demonstrates promising directions in the search for specific methods of prevention and correction of these pathological conditions.
这篇综述致力于将现代科学研究关于胆汁酸作为一类新型甾体激素的作用的结果进行系统化、分类和概括。本文介绍了胆汁酸参与调节机体能量代谢、体重控制以及肥胖症、糖尿病、胰岛素抵抗和心血管疾病发病机制的证据。特别关注胆汁酸在控制机体非特异性能量消耗中的作用。分析了应用有关负责胆汁酸激素调节作用发展的膜和细胞内受体的新数据的方面。作者认为，关于胆汁酸在调节机体功能中的作用的现代数据可以更深入地了解体重紊乱和相关心血管疾病的发病机制。该综述展示了在寻找预防和纠正这些病理状况的具体方法方面的有前景的方向。
