Frezoulis P S, Oikonomidis I L, Saridomichelakis M N, Kasabalis D, Pappa A, Bouza-Rapti P, Chochlios T, Tsouloufi T K, Kritsepi-Konstantinou M, Soubasis N
Southfields Veterinary Specialists, Essex, SS15 6TP, UK.
Faculty of Health Sciences, School of Veterinary Science, Aristotle University of Thessaloniki, 541 24, Thessaloniki, Greece.
J Small Anim Pract. 2022 Mar;63(3):197-202. doi: 10.1111/jsap.13445. Epub 2021 Nov 19.
To determine the prevalence of stress hyperglycaemia in sick cats, and to investigate the association of stress hyperglycaemia with systemic inflammatory response syndrome and outcome.
Medical records (2004 to 2013) from sick cats admitted to the Medicine Unit of a Veterinary Teaching Hospital were retrospectively reviewed. Cases were enrolled if a serum glucose measurement and a complete medical record were available. Cats that were healthy, hypoglycaemic, diabetic, sedated or had a previous administration of drugs (apart from vaccination and deworming) were excluded.
The study included 647 cats; stress hyperglycaemia (serum glucose >8.3 mmol/L) was found in 194 (30%) cats, while 453 (70%) cats were normoglycaemic. The prevalence of systemic inflammatory response syndrome was significantly higher in cats with stress hyperglycaemia (25/174, 14.4%) compared to normoglycaemic cats (26/399, 6.5%). Significantly, more cats with stress hyperglycaemia were hospitalised [97/194 (50.0%)] compared to normoglycaemic cats [171/453 (37.7%)]. However, the median duration of hospitalisation was not significantly different [4 (1 to 26) days and 4 (1 to 24) days, respectively]. The prevalence of cats with negative outcome was not significantly different between the two groups (cats with stress hyperglycaemia: 37.1%, normoglycaemic cats: 33.9%). Nonetheless, when modelling of outcome prediction included breed, age, stress hyperglycaemia and disease category as factors, cats with stress hyperglycaemia had 2.8 times the odds to have a negative outcome (95% confidence interval: 1.3 to 6.4).
Based on the cut-off employed in this study, Stress hyperglycaemia, as defined by the cut-off is common in sick cats. Stress hyperglycaemia is associated with systemic inflammatory response syndrome development and seem to be a negative prognostic indicator.
确定患病猫应激性高血糖的患病率，并调查应激性高血糖与全身炎症反应综合征及预后的关联。
对一家兽医教学医院内科收治的患病猫（2004年至2013年）的病历进行回顾性研究。若有血清葡萄糖测量值和完整病历则纳入病例。排除健康、低血糖、糖尿病、镇静或曾使用过药物（除疫苗接种和驱虫外）的猫。
该研究纳入647只猫；194只（30%）猫出现应激性高血糖（血清葡萄糖>8.3 mmol/L），而453只（70%）猫血糖正常。与血糖正常的猫（26/399，6.5%）相比，应激性高血糖的猫全身炎症反应综合征的患病率显著更高（25/174，14.4%）。值得注意的是，与血糖正常的猫[171/453（37.7%）]相比，应激性高血糖的猫住院的更多[97/194（50.0%）]。然而，住院时间中位数无显著差异[分别为4（1至26）天和4（1至24）天]。两组猫不良预后的患病率无显著差异（应激性高血糖的猫：37.1%，血糖正常的猫：33.9%）。尽管如此，当将品种、年龄、应激性高血糖和疾病类别作为因素进行预后预测建模时，应激性高血糖的猫出现不良预后的几率是血糖正常猫的2.8倍（95%置信区间：1.3至6.4）。
基于本研究采用的临界值，该临界值定义的应激性高血糖在患病猫中很常见。应激性高血糖与全身炎症反应综合征的发生相关，似乎是一个不良预后指标。
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