Krajnc Matej, Stern Tomer, Zankoc Clément
Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Phys Rev Lett. 2021 Nov 5;127(19):198103. doi: 10.1103/PhysRevLett.127.198103.
Active cell-junction remodeling is important for tissue morphogenesis, yet its underlying physics is not understood. We study a mechanical model that describes junctions as dynamic active force dipoles. Their instability can trigger cell intercalations by a critical collapse. Nonlinearities in tissue's elastic response can stabilize the collapse either by a limit cycle or condensation of junction lengths at cusps of the energy landscape. Furthermore, active junction networks undergo collective instability to drive active in-plane ordering or develop a limit cycle of collective oscillations, which extends over regions of the energy landscape corresponding to distinct network topologies.
活跃的细胞连接重塑对于组织形态发生很重要，但其潜在的物理学原理尚不清楚。我们研究了一个力学模型，该模型将连接描述为动态的活跃力偶极子。它们的不稳定性可通过临界坍塌触发细胞插入。组织弹性响应中的非线性可以通过极限环或能量景观尖点处连接长度的凝聚来稳定坍塌。此外，活跃的连接网络会经历集体不稳定性，以驱动平面内的活跃有序排列或形成集体振荡的极限环，该极限环延伸到与不同网络拓扑相对应的能量景观区域。
