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经皮内镜下坏死组织清除术治疗气肿性胰腺炎 1 例报告。

Percutaneous endoscopic necrosectomy in a patient with emphysematous pancreatitis: A case report.

机构信息

Division of Gastroenterology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64, Daeheung-ro, Jung-gu, Daejeon, Republic of Korea.

Department of Radiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64, Daeheung-ro, Jung-gu, Daejeon, Republic of Korea.

出版信息

Medicine (Baltimore). 2021 Nov 19;100(46):e27905. doi: 10.1097/MD.0000000000027905.

Abstract

RATIONALE

Emphysematous pancreatitis, a rare complication of acute necrotizing pancreatitis with a high mortality rate, is associated with gas-forming bacteria. When using the step-up approach for treating emphysematous pancreatitis, it is preferable to delay drainage interventions for 4 weeks. However, percutaneous drainage may be necessary, even in the early phase of acute pancreatitis, for a patient whose sepsis deteriorates despite optimal medical management. Percutaneous drainage can then be followed by endoscopic necrosectomy through the percutaneous tract.

PATIENT CONCERNS

A 52-year-old man was transferred to our hospital for treatment of sepsis and multiorgan failure associated with emphysematous pancreatitis.

DIAGNOSIS

An abdominal computed tomography scan had shown pancreatic and peripancreatic necrosis, along with extensive gas bubbles.

INTERVENTIONS

Despite optimal medical management, the patient's condition continued to deteriorate, and it became necessary to insert 2 percutaneous catheter drainages (PCDs), even though the patient was still in the early phase of pancreatitis. Each PCD was upsized and irrigated with sterile saline by an interventional radiologist twice a week. The infected necrosis around the tail of the pancreas was completely resolved after PCD. However, PCD through the transperitoneal route did not resolve necrosis around the pancreatic head. Following the PCDs, percutaneous pancreatic necrosectomy using an ultra-slim upper endoscope was performed, after which the patient recovered quickly and was discharged.

OUTCOMES

Follow-up computed tomography was performed 12 weeks after the patient was discharged, and it showed complete resolution of the walled-off necrosis. The patient's condition improved without any fluid collection or complications.

LESSONS

PCD can be used in the early phase of emphysematous pancreatitis for patients who continue to deteriorate due to sepsis. This can easily be followed, if necessary, by percutaneous pancreatic necrosectomy using an ultra-slim endoscope.

摘要

背景

气肿性胰腺炎是急性坏死性胰腺炎的罕见并发症,死亡率高,与产气细菌有关。对于气肿性胰腺炎,采用逐步升级的方法进行治疗时,最好延迟 4 周进行引流干预。然而,对于尽管经过最佳药物治疗但败血症仍恶化的患者,即使在急性胰腺炎的早期阶段,也可能需要进行经皮引流。随后可以通过经皮途径进行内镜坏死组织清除术。

病例介绍

一名 52 岁男性因气肿性胰腺炎相关的败血症和多器官衰竭转入我院治疗。

影像学检查

腹部 CT 扫描显示胰腺和胰周坏死,伴有广泛的气泡。

治疗经过

尽管经过最佳药物治疗,但患者的病情仍持续恶化,需要插入 2 根经皮导管引流(PCD),尽管患者仍处于胰腺炎的早期阶段。每周由介入放射科医生对每个 PCD 进行两次扩管和无菌生理盐水冲洗。胰腺尾部感染性坏死在 PCD 后完全消退。然而,经腹膜途径的 PCD 并未解决胰头部周围的坏死。在 PCD 之后,使用超细上消化道内镜进行经皮胰腺坏死组织清除术,之后患者迅速恢复并出院。

出院后 12 周进行的随访 CT 显示,完全包裹性坏死已完全消退。患者的病情改善,无积液或并发症。

经验教训

对于因败血症持续恶化的气肿性胰腺炎患者,可在早期阶段使用 PCD。如果需要,可通过超细内镜进行经皮胰腺坏死组织清除术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f1/8601313/f120645a6370/medi-100-e27905-g001.jpg

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