Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, People's Republic of China.
Phytochemistry. 2022 Feb;194:113015. doi: 10.1016/j.phytochem.2021.113015. Epub 2021 Nov 16.
A phytochemical investigation on chemical constituents from the rhizomes of Menispermum dauricum DC. identified eight undescribed dimeric alkaloids with structurally diverse monomeric isoquinoline. Alkaloid structures were elucidated by a combination of spectroscopic data analyses and time-dependent density functional theory (TDDFT) ECD calculation. The isolates were evaluated for inhibitory effect on dopamine D1 receptor and compound 1 exhibited potent D1 receptor antagonistic activity with an IC value of 8.4 ± 2.0 μM.
从防己科千金藤属植物头花千金藤根茎中分离得到 8 个结构新颖的二聚体生物碱，这些生物碱均含有结构多样的单体异喹啉。通过波谱数据分析和时间依赖的密度泛函理论（TDDFT）ECD 计算相结合的方法阐明了生物碱的结构。对这些分离得到的化合物进行了多巴胺 D1 受体抑制活性评价，其中化合物 1 对多巴胺 D1 受体具有较强的拮抗活性，IC 值为 8.4±2.0 μM。
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